Purpose. The current study was designed to investigate the impact of blood urea nitrogen (BUN), serum uric acid (UA), and cystatin (CysC) on the short-term outcomes and prognosis of colorectal cancer (CRC) patients undergoing radical surgery. Methods. CRC patients who underwent radical resection were included from Jan 2011 to Jan 2020 in a single clinical centre. The short-term outcomes, overall survival (OS), and disease-free survival (DFS) were compared in different groups. A Cox regression analysis was conducted to identify independent risk factors for OS and DFS. Results. A total of 2047 CRC patients who underwent radical resection were included in the current study. Patients in the abnormal BUN group had a longer hospital stay () and more overall complications () than that of the normal BUN group. The abnormal CysC group had longer hospital stay (), more overall complications (), and more major complications () than the normal CysC group. Abnormal CysC was associated with worse OS and DFS for CRC patients in tumor stage I (). In Cox regression analysis, age (, HR = 1.041, 95% CI = 1.029–1.053), tumor stage (, HR = 2.134, 95% CI = 1.828–2.491), and overall complications (, HR = 1.499, 95% CI = 1.166–1.928) were independent risk factors for OS. Similarly, age (, HR = 1.026, 95% CI = 1.016–1.037), tumor stage (, HR = 2.053, 95% CI = 1.788–2.357), and overall complications (, HR = 1.440, 95% CI = 1.144–1.814) were independent risk factors for DFS. Conclusion. In conclusion, abnormal CysC was significantly associated with worse OS and DFS at TNM stage I, and abnormal CysC and BUN were related to more postoperative complications. However, preoperative BUN and UA in the serum might not affect OS and DFS for CRC patients who underwent radical resection.

中文翻译：

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与肾功能相关的血清参数对接受根治性手术的结直肠癌患者的短期结果和预后的影响

目的。本研究旨在探讨血尿素氮 (BUN)、血清尿酸 (UA) 和胱抑素 (CysC) 对接受根治性手术的结直肠癌 (CRC) 患者的短期结果和预后的影响。方法。从 2011 年 1 月到 2020 年 1 月，在一个临床中心纳入了接受根治性切除术的 CRC 患者。比较不同组间的短期结局、总生存期（OS）和无病生存期（DFS）。进行 Cox 回归分析以确定 OS 和 DFS 的独立风险因素。结果。本研究共纳入 2047 名接受根治性切除术的 CRC 患者。BUN异常组患者住院时间较长（)和更多的综合并发症 ()比正常的 BUN 组。CysC异常组住院时间较长（),更多的综合并发症 (),以及更多的主要并发症 ()比正常的 CysC 组。异常的 CysC 与肿瘤 I 期 CRC 患者较差的 OS 和 DFS 相关（). 在 Cox 回归分析中，年龄 (, HR = 1.041, 95% CI = 1.029–1.053), 肿瘤分期 (, HR = 2.134, 95% CI = 1.828–2.491), 总体并发症 (, HR = 1.499, 95% CI = 1.166–1.928) 是 OS 的独立危险因素。同样，年龄（, HR = 1.026, 95% CI = 1.016–1.037), 肿瘤分期 (, HR = 2.053, 95% CI = 1.788–2.357), 总体并发症 (, HR = 1.440, 95% CI = 1.144–1.814) 是 DFS 的独立危险因素。结论。总之，CysC 异常与 TNM I 期较差的 OS 和 DFS 显着相关，异常的 CysC 和 BUN 与更多的术后并发症相关。然而，血清中的术前 BUN 和 UA 可能不会影响接受根治性切除术的 CRC 患者的 OS 和 DFS。