For the return of polygenic risk scores to become an acceptable clinical practice in psychiatry, receipt of polygenic risk scores must be associated with minimal harm and changes in behavior that decrease one's risk for developing a psychiatric outcome. Data from a randomized controlled trial was used to assess the impact of different levels of hypothetical polygenic risk scores for alcohol use disorder on psychological distress, risk perception, and intentions to change drinking behaviors. The analytic sample consisted of 325 participants recruited from an urban, public university. Results demonstrated that there were significant increases in psychological distress as the level of genetic risk for alcohol use disorder increased. In addition, the perceived chance of developing alcohol use disorder significantly increased as the level of genetic risk increased. Promisingly, a greater proportion of participants indicated that they would intend to engage in follow-up behaviors, such as seeking additional information, talking to a healthcare provider about risk, and reducing drinking behaviors, as the level of genetic risk increased. Returning polygenic risk scores for alcohol use disorder in a clinical setting has the potential to promote risk-reducing behavior change, especially with increasing levels of genetic risk. The study was registered on ClinicalTrials.gov (Identifier: NCT05143073).

中文翻译：

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接受酒精使用障碍多基因风险评分对心理困扰、风险感知和减少饮酒意愿的影响

为了使多基因风险评分的回归成为精神病学中可接受的临床实践，多基因风险评分的接收必须与最小的伤害和行为改变相关联，从而降低一个人发生精神病结果的风险。一项随机对照试验的数据用于评估不同水平的酒精使用障碍假设多基因风险评分对心理困扰、风险认知和改变饮酒行为意图的影响。分析样本由从一所城市公立大学招募的 325 名参与者组成。结果表明，随着酒精使用障碍遗传风险水平的增加，心理困扰显着增加。此外，随着遗传风险水平的增加，人们认为患酒精使用障碍的可能性也显着增加。令人鼓舞的是，更多的参与者表示，随着遗传风险水平的增加，他们打算采取后续行为，例如寻求更多信息、与医疗保健提供者讨论风险以及减少饮酒行为。在临床环境中返回酒精使用障碍的多基因风险评分有可能促进降低风险的行为改变，特别是在遗传风险水平不断增加的情况下。该研究已在 ClinicalTrials.gov 上注册（标识符：NCT05143073）。