The development and progression of tumors in human tissues extensively rely on its surrounding environment, that is, tumor microenvironment which includes a variety of cells, molecules, and blood vessels. These components are modified, organized, and integrated to support and facilitate the growth, invasion, and metabolism of tumor cells, suggesting them as potential therapeutic targets in anticancer treatment. An increasing number of pharmacological agents have been developed and clinically applied to target the oncogenic components in the tumor microenvironment, and in this review, we will summarize these pharmacological agents that directly or indirectly target the cellular or molecular components in the tumor microenvironment. However, difficulties and challenges still exist in this field, which will also be reported in this literature.

中文翻译：

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针对肿瘤微环境的抗肿瘤治疗

人体组织中肿瘤的发生、发展广泛依赖于其周围环境，即肿瘤微环境，包括多种细胞、分子和血管。这些成分经过修饰、组织和整合以支持和促进肿瘤细胞的生长、侵袭和代谢，表明它们是抗癌治疗中的潜在治疗靶点。越来越多的药物已被开发并临床应用于靶向肿瘤微环境中的致癌成分，在这篇综述中，我们将总结这些直接或间接靶向肿瘤微环境中的细胞或分子成分的药物。然而，这一领域仍然存在困难和挑战，这也将在本文中有所报道。