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Clinical Features Focusing on Extraintestinal Manifestations in Japanese Patients with Inflammatory Bowel Diseases: Far East 1000
Digestion ( IF 3.2 ) Pub Date : 2023-03-09 , DOI: 10.1159/000529816 Yuki Ohta 1 , Takashi Taida 2 , Jun Kato 2 , Sadahisa Ogasawara 2 , Yuhei Oyama 2 , Yukiyo Mamiya 2 , Hayato Nakazawa 2 , Ryosuke Horio 2 , Chihiro Goto 2 , Satsuki Takahashi 2 , Akane Kurosugi 2 , Michiko Sonoda 2 , Wataru Shiratori 3 , Tatsuya Kaneko 2 , Yuya Yokoyama 2 , Naoki Akizue 3 , Hideaki Ishigami 4 , Hirotaka Koseki 5 , Kenichiro Okimoto 2 , Keiko Saito 2 , Masaya Saito 6 , Tomoaki Matsumura 2 , Tomoo Nakagawa 2 , Yoshio Masuya 4 , Yoshihiro Fukuda 6 , Yoshio Kitsukawa 5 , Haruhisa Shimura 7 , Toshio Tsuyuguchi 2 , Naoya Kato 2
Digestion ( IF 3.2 ) Pub Date : 2023-03-09 , DOI: 10.1159/000529816 Yuki Ohta 1 , Takashi Taida 2 , Jun Kato 2 , Sadahisa Ogasawara 2 , Yuhei Oyama 2 , Yukiyo Mamiya 2 , Hayato Nakazawa 2 , Ryosuke Horio 2 , Chihiro Goto 2 , Satsuki Takahashi 2 , Akane Kurosugi 2 , Michiko Sonoda 2 , Wataru Shiratori 3 , Tatsuya Kaneko 2 , Yuya Yokoyama 2 , Naoki Akizue 3 , Hideaki Ishigami 4 , Hirotaka Koseki 5 , Kenichiro Okimoto 2 , Keiko Saito 2 , Masaya Saito 6 , Tomoaki Matsumura 2 , Tomoo Nakagawa 2 , Yoshio Masuya 4 , Yoshihiro Fukuda 6 , Yoshio Kitsukawa 5 , Haruhisa Shimura 7 , Toshio Tsuyuguchi 2 , Naoya Kato 2
Affiliation
Background: Patients with inflammatory bowel diseases (IBD) can develop extraintestinal manifestations (EIMs) during the disease course, which sometimes impact their quality of life. Objectives: This study aimed to clarify the prevalence and types of EIMs using a hospital-based IBD cohort in Japan. Methods: A patient cohort with IBD was established in 2019, as participated by 15 hospitals in Chiba Prefecture of Japan. Using this cohort, the prevalence and types of EIMs, which are defined based on previous reports and the Japanese guidelines, were investigated. Results: This cohort enrolled 728 patients, including 542 ulcerative colitis (UC) and 186 Crohn’s disease (CD). Of these patients with IBD, 10.0% were identified with one or more EIMs (57 (10.5%) with UC and 16 (8.6%) with CD). Arthropathy and arthritis were the most common EIM in 23 (4.2%) patients with UC, followed by primary sclerosing cholangitis (PSC) (2.6%). Arthropathy and arthritis were also the most common in patients with CD, but no cases of PSC were observed. EIMs were more frequently observed in patients with IBD treated by specialists than in those treated by non-specialists (12.7% vs. 5.5%, p = 0.011). The incidence of EIMs in patients with IBD was not significantly different over time. Conclusions: The prevalence and types of EIMs in our hospital-based cohort in Japan did not significantly differ from those reported in previous or Western studies. However, the incidence might be underestimated due to the limited ability of non-IBD specialists to discover and describe EIMs in patients with IBD.
Digestion
中文翻译：
日本炎症性肠病患者肠外表现的临床特征：远东 1000
背景：炎症性肠病（IBD）患者在病程中可能会出现肠外表现（EIM），这有时会影响他们的生活质量。目的：本研究旨在通过日本医院 IBD 队列来阐明 EIM 的患病率和类型。方法： 2019 年建立了由日本千叶县 15 家医院参与的 IBD 患者队列。使用该队列，对根据之前的报告和日本指南定义的 EIM 的流行率和类型进行了调查。结果：该队列入组了 728 名患者，其中包括 542 名溃疡性结肠炎（UC）患者和 186 名克罗恩病（CD）患者。在这些 IBD 患者中，10.0% 的患者患有一种或多种 EIM（57 例 (10.5%) 患有 UC，16 例 (8.6%) 患有 CD）。关节病和关节炎是 23 名 UC 患者 (4.2%) 中最常见的 EIM，其次是原发性硬化性胆管炎 (PSC) (2.6%)。关节病和关节炎也是 CD 患者中最常见的，但没有观察到 PSC 病例。EIM 在接受专科医生治疗的 IBD 患者中比接受非专科医生治疗的 IBD 患者中更常见（12.7% vs. 5.5%， p = 0.011）。随着时间的推移，IBD 患者的 EIM 发生率没有显着差异。结论：我们日本医院队列中 EIM 的患病率和类型与之前或西方研究中报告的没有显着差异。然而，由于非 IBD 专家发现和描述 IBD 患者 EIM 的能力有限，该发病率可能被低估。
消化
更新日期：2023-03-09
Digestion
中文翻译：
日本炎症性肠病患者肠外表现的临床特征：远东 1000
背景：炎症性肠病（IBD）患者在病程中可能会出现肠外表现（EIM），这有时会影响他们的生活质量。目的：本研究旨在通过日本医院 IBD 队列来阐明 EIM 的患病率和类型。方法： 2019 年建立了由日本千叶县 15 家医院参与的 IBD 患者队列。使用该队列，对根据之前的报告和日本指南定义的 EIM 的流行率和类型进行了调查。结果：该队列入组了 728 名患者，其中包括 542 名溃疡性结肠炎（UC）患者和 186 名克罗恩病（CD）患者。在这些 IBD 患者中，10.0% 的患者患有一种或多种 EIM（57 例 (10.5%) 患有 UC，16 例 (8.6%) 患有 CD）。关节病和关节炎是 23 名 UC 患者 (4.2%) 中最常见的 EIM，其次是原发性硬化性胆管炎 (PSC) (2.6%)。关节病和关节炎也是 CD 患者中最常见的，但没有观察到 PSC 病例。EIM 在接受专科医生治疗的 IBD 患者中比接受非专科医生治疗的 IBD 患者中更常见（12.7% vs. 5.5%， p = 0.011）。随着时间的推移，IBD 患者的 EIM 发生率没有显着差异。结论：我们日本医院队列中 EIM 的患病率和类型与之前或西方研究中报告的没有显着差异。然而，由于非 IBD 专家发现和描述 IBD 患者 EIM 的能力有限，该发病率可能被低估。
消化
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