In this work, poly(N,N-diethylacrylamide) (PDEA) hydrogel films were polymerized on glassy carbon (GC) electrode surface, and isoniazid (INH) was chosen as an electroactive pharmaceutical molecule probe, aiming to investigate the switchable electrochemical behaviors of INH. Determining the contents of INH tablets under different external stimuli conditions and constructing its logic gate computing systems. The triple-sensitive electrochemical CV behaviors of INH on this film system toward pH, temperature and salt concentration were observed and explored. Thus, a 3-input/8-output combinational pharmaceutical logic gate network and a 3-to-8 decoder were designed and constructed based on the stimulus-responsive characteristics of the electrochemical response of INH on PDEA hydrogel-modified electrodes. Besides, the relationship between the oxidation peak current (I_pa) and concentration of INH (C_INH) was studied by the differential pulse voltammetry (DPV) method. Apply this film system, and the INH tablets could be switchable detected. The construction of the logic-gate computing system based on isoniazid drug molecule may provide a novel approach and model to design new style drug sensors, which might be applied to intelligent medical diagnostics and drug release.

在这项工作中，聚（N，N-二乙基丙烯酰胺) (PDEA) 水凝胶薄膜聚合在玻碳 (GC) 电极表面，并选择异烟肼 (INH) 作为电活性药物分子探针，旨在研究异烟肼的可切换电化学行为。测定异烟肼片在不同外界刺激条件下的含量并构建其逻辑门计算系统。观察和探索了 INH 在该薄膜系统上对 pH、温度和盐浓度的三重敏感电化学 CV 行为。因此，基于 PDEA 水凝胶修饰电极上 INH 的电化学响应的刺激响应特性，设计并构建了 3 输入/8 输出组合药物逻辑门网络和 3 到 8 解码器。此外，氧化峰值电流之间的关系（I _pa ) 和 INH ( C _INH ) 的浓度是通过差分脉冲伏安法 (DPV) 法研究的。应用此薄膜系统，异烟肼片可切换检测。构建基于异烟肼药物分子的逻辑门计算系统可为设计新型药物传感器提供一种新的途径和模型，可应用于智能医学诊断和药物释放。