SARS-CoV-2 can be vertically transmitted from the mother to the fetus and the neonate. This transmission route is rare compared to the environmental or horizontal spread and therefore, the risk can be deemed inconsequential by some medical providers. However, severe, although just as rare, feto-neonatal consequences are possible: fetal demise, severe/critical neonatal COVID-19 and multi-inflammatory syndrome (MIS-N) have been described. Therefore, it is important for the clinicians to know the mechanism of vertical transmission, how to recognize this, and how to deal with neonatal COVID-19 and MIS-N. Our knowledge about this field has significantly increased in the last three years. This is a summary of the pathophysiology, diagnostics, and therapeutics of vertical SARS-CoV-2 transmission that clinicians apply in their clinical practice.

SARS-CoV-2 可以从母亲垂直传播给胎儿和新生儿。与环境或水平传播相比，这种传播途径很少见，因此，一些医疗提供者认为风险无关紧要。然而，严重但同样罕见的胎儿新生儿后果是可能的：已经描述了胎儿死亡、严重/危重新生儿 COVID-19 和多炎症综合征 (MIS-N)。因此，临床医生了解垂直传播的机制、如何识别这一点以及如何应对新生儿 COVID-19 和 MIS-N 非常重要。在过去三年中，我们对该领域的了解有了显着增加。这是临床医生在其临床实践中应用的 SARS-CoV-2 垂直传播的病理生理学、诊断学和治疗学的总结。