Memory T (Tm) cells protect against Ags that they have previously contacted with a fast and robust response. Therefore, developing long-lived Tm cells is a prime goal for many vaccines and therapies to treat human diseases. The remarkable characteristics of Tm cells have led scientists and clinicians to devise methods to make Tm cells more useful. Recently, Tm cells have been highlighted for their role in coronavirus disease 2019 vaccines during the ongoing global pandemic. The importance of Tm cells in cancer has been emerging. However, the precise characteristics and functions of Tm cells in these diseases are not completely understood. In this review, we summarize the known characteristics of Tm cells and their implications in the development of vaccines and immunotherapies for human diseases. In addition, we propose to exploit the beneficial characteristics of Tm cells to develop strategies for effective vaccines and overcome the obstacles of immunotherapy.

中文翻译：

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记忆 CD8+ T 细胞在人类疾病免疫治疗中的作用。

记忆 T (Tm) 细胞可以防止它们以前接触过的 Ags，反应快速而有力。因此，开发长寿的 Tm 细胞是许多治疗人类疾病的疫苗和疗法的首要目标。Tm 细胞的显着特性促使科学家和临床医生设计出使 Tm 细胞更有用的方法。最近，在持续的全球大流行期间，TM 细胞因其在 2019 冠状病毒病疫苗中的作用而受到关注。Tm 细胞在癌症中的重要性已经显现。然而，Tm 细胞在这些疾病中的确切特征和功能尚不完全清楚。在这篇综述中，我们总结了 Tm 细胞的已知特征及其在人类疾病疫苗和免疫疗法开发中的意义。此外，