For decades, bovine jugular vein conduits (BJV) and classic cryopreserved homografts have been the two most widely used options for pulmonary valve replacement (PVR) in congenital heart disease. More recently, decellularized pulmonary homografts (DPH) have provided an alternative avenue for PVR. Matched comparison of patients who received DPH for PVR with patients who received bovine jugular vein conduits (BJV) considering patient age group, type of heart defect, and previous procedures. 319 DPH patients were matched to 319 BJV patients; the mean age of BJV patients was 15.3 (SD 9.5) years versus 19.1 (12.4) years in DPH patients (p = 0.001). The mean conduit diameter was 24.5 (3.5) mm for DPH and 20.3 (2.5) mm for BJV (p < 0.001). There was no difference in survival rates between the two groups after 10 years (97.0 vs. 98.1%, p = 0.45). The rate of freedom from endocarditis was significantly lower for BJV patients (87.1 vs. 96.5%, p = 0.006). Freedom from explantation was significantly lower for BJV at 10 years (81.7 vs. 95.5%, p = 0.001) as well as freedom from any significant degeneration at 10 years (39.6 vs. 65.4%, p < 0.001). 140 Patients, matched for age, heart defect type, prior procedures, and conduit sizes of 20–22 mm (± 2 mm), were compared separately; mean age BJV 8.7 (4.9) and DPH 9.5 (7.3) years (p = n.s.). DPH showed 20% higher freedom from explantation and degeneration in this subgroup (p = 0.232). Decellularized pulmonary homografts exhibit superior 10-year results to bovine jugular vein conduits in PVR.

几十年来，牛颈静脉导管 (BJV) 和经典的冷冻保存同种移植物一直是先天性心脏病肺动脉瓣置换术 (PVR) 中使用最广泛的两种选择。最近，脱细胞肺同种移植物 (DPH) 为 PVR 提供了另一种途径。考虑患者年龄组、心脏缺陷类型和既往手术，对接受 DPH 进行 PVR 的患者与接受牛颈静脉导管 (BJV) 的患者进行匹配比较。319 名 DPH 患者匹配 319 名 BJV 患者；BJV 患者的平均年龄为 15.3 (SD 9.5) 岁，而 DPH 患者为 19.1 (12.4) 岁 ( p  = 0.001)。DPH 的平均导管直径为 24.5 (3.5) mm，BJV 的平均导管直径为 20.3 (2.5) mm ( p < 0.001)。10 年后两组的生存率没有差异（97.0 对 98.1%，p  = 0.45）。BJV 患者的无心内膜炎率明显较低（87.1 对 96.5%，p  = 0.006）。BJV 在 10 年时无外植的自由度显着降低（81.7 对 95.5%，p  = 0.001），在 10 年时无任何显着退化（39.6 对 65.4%，p  < 0.001）。140 名患者的年龄、心脏缺陷类型、既往手术和导管尺寸为 20-22 毫米（± 2 毫米）匹配，分别进行比较；平均年龄 BJV 8.7 (4.9) 和 DPH 9.5 (7.3) 岁 ( p  = ns)。在该亚组中，DPH 的外植和退化自由度提高了 20%（p = 0.232）。脱细胞肺同种移植物在 PVR 中表现出优于牛颈静脉导管的 10 年结果。