Purpose: The aims of this study were to study use of tissue glue instead of conventional suturing and to secure I-125 plaque in human eyes with uveal melanoma. Methods: We studied 6 patients with choroidal melanoma undergoing plaque radiotherapy who were found to have thin sclera intraoperatively. Following tumor localization and plaque placement, tissue glue was applied over and around the plaque surface. The plaque was held securely in all cases. Conjunctivoplasty was performed with 7-0 vicryl sutures to ensure complete coverage and stability of the plaque. At the time of plaque removal, the tissue glue clot was in place with plaque secured. The clot and plaque were removed without difficulty. Results: In all 6 cases, the tissue glue secured the plaque in place for the required radiation duration (mean 117.6 h (hrs), median 103.1 h, range 101.6–162.5 h) delivering a tumor apex dose (mean 63.6 cGy/h, median 69.6 cGy/h, range 44.7–70.5 cGy/h). At the time of plaque removal, the plaque was in the designated position without displacement in all cases. There were no toxicities from the tissue glue. Conclusions: Tissue glue can serve as an alternative for fixation of plaque radiotherapy to the sclera without the need for suturing. This technique might be useful in eyes with thin sclera.


中文翻译：

---

组织胶粘附用于人类葡萄膜黑色素瘤斑块放射治疗：初步经验

目的：本研究的目的是研究使用组织胶代替传统缝合，并在患有葡萄膜黑色素瘤的人眼中固定 I-125 斑块。方法：我们研究了 6 例接受斑块放疗的脉络膜黑色素瘤患者，这些患者术中发现巩膜变薄。在肿瘤定位和斑块放置后，将组织胶涂在斑块表面上和周围。在所有情况下，牌匾都被牢固地固定着。使用 7-0 vicryl 缝线进行结膜成形术，以确保斑块的完全覆盖和稳定性。在去除斑块时，组织胶凝块就位，斑块固定。凝块和斑块被毫无困难地移除。结果：在所有 6 例中，组织胶在所需的辐射持续时间（平均 117.6 小时（小时），中位数 103.1 小时，范围 101.6–162.5 小时）内将斑块固定到位，提供肿瘤顶端剂量（平均 63.6 cGy/h，中位数 69.6 cGy/h，范围 44.7–70.5 cGy/h）。清除菌斑时，所有病例菌斑均在指定位置，无移位。组织胶没有毒性。结论：组织胶可以作为斑块放疗固定在巩膜上的替代方法，无需缝合。这种技术可能对巩膜薄的眼睛有用。