Migraine is a complex neurovascular pain disorder linked to the meninges, a border tissue innervated by neuropeptide-containing primary afferent fibers chiefly from the trigeminal nerve. Electrical or mechanical stimulation of this nerve surrounding large blood vessels evokes headache patterns as in migraine, and the brain, blood, and meninges are likely sources of headache triggers. Cerebrospinal fluid may play a significant role in migraine by transferring signals released from the brain to overlying pain-sensitive meningeal tissues, including dura mater. Interactions between trigeminal afferents, neuropeptides, and adjacent meningeal cells and tissues cause neurogenic inflammation, a critical target for current prophylactic and abortive migraine therapies. Here we review the importance of the cranial meninges to migraine headaches, explore the properties of trigeminal meningeal afferents, and briefly review emerging concepts, such as meningeal neuroimmune interactions, that may one day prove therapeutically relevant.

中文翻译：

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脑膜机制和偏头痛的联系

偏头痛是一种与脑膜相关的复杂的神经血管疼痛疾病，脑膜是一种由主要来自三叉神经的含有神经肽的初级传入纤维支配的边界组织。对大血管周围的神经进行电或机械刺激会引起偏头痛等头痛模式，而大脑、血液和脑膜可能是头痛的触发源。脑脊液可能通过将从大脑释放的信号传递到覆盖的疼痛敏感脑膜组织（包括硬脑膜）而在偏头痛中发挥重要作用。三叉神经传入神经、神经肽以及邻近的脑膜细胞和组织之间的相互作用引起神经源性炎症，这是当前预防性和失败性偏头痛治疗的关键目标。在这里，我们回顾了颅脑膜对偏头痛的重要性，探讨了三叉神经脑膜传入的特性，并简要回顾了新兴概念，例如脑膜神经免疫相互作用，这些概念有一天可能被证明具有治疗相关性。