Major depressive disorder affects nearly 20% of people during their lifetime. A growing body of evidence supports the theory that neuroinflammation plays a prominent role in the neurobiology of depression, which implicates glutamate and gamma aminobutyric acid as key factors in the pathophysiology of the disease process. This article reviews the pathologic pathways of glutamate excess in the central nervous system and how they may be implicated in the underlying disorder of treatment-resistant depression and targeted for treatment.

中文翻译：

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神经炎症和谷氨酸兴奋性毒性在难治性抑郁症中的作用

重度抑郁症影响近 20% 的人一生。越来越多的证据支持这样的理论，即神经炎症在抑郁症的神经生物学中发挥着重要作用，这表明谷氨酸和γ-氨基丁酸是疾病过程病理生理学的关键因素。本文回顾了中枢神经系统中谷氨酸过量的病理途径，以及它们如何与难治性抑郁症的潜在疾病有关以及如何进行靶向治疗。