Abstract

Purpose

Event-related desynchronisation (ERD) and event-related synchronisation (ERS) reflect pain perception and integration of the nociceptive sensory inputs. This may contribute to the understanding of how neurophysiological markers of Knee Osteoarthritis (KOA) patients can differ from control individuals, which would improve aspects such as prediction and prognosis. We performed a cross-sectional analysis of our cohort study (DEFINE cohort), KOA arm, with 71 patients, compared with 65 control participants. The study aimed to examine possible differences between ERD and ERS in control participants compared to Knee Osteoarthritis (KOA) patients when adjusting for important covariates.

Materials and methods

We performed independent multivariate regression models considering as dependent variables the power value related to ERD and ERS for four different sensorimotor tasks (Motor Execution, Motor Imagery, Active Observation and Passive Observation) and four sensorimotor oscillations (Alpha, Beta, Low Beta, and High Beta), each model, controlled by age and sex.

Results

We demonstrate that the differences between KOA and healthy subjects are frequency specific, as most differences are in the beta bandwidth range. Also, we observed that subjects in the KOA group had significantly higher ERD and ERS. This may be correlated to the amount of lack of brain organisation and a subsequent attempt at compensation induced by KOA.

Conclusions

Our findings strengthen the notion that subjects with KOA have a higher degree of brain plasticity changes that are also likely correlated to the degree of compensation and behavioural dysfunction.

中文翻译：

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膝骨关节炎 (KOA) 的神经可塑性变化以运动抑制任务期间事件相关的去同步化/同步化为索引

摘要

目的

与事件相关的去同步化 (ERD) 和与事件相关的同步化 (ERS) 反映了痛觉和伤害性感觉输入的整合。这可能有助于理解膝骨关节炎 (KOA) 患者的神经生理学标志物与对照个体有何不同，这将改善预测和预后等方面。我们对我们的队列研究（DEFINE 队列）进行了横断面分析，KOA 组有 71 名患者和 65 名对照组参与者。该研究旨在检查对照参与者与膝骨关节炎 (KOA) 患者在调整重要协变量时 ERD 和 ERS ​​之间可能存在的差异。

材料和方法

我们执行了独立的多元回归模型，将与 ERD 和 ERS ​​相关的功率值作为因变量，用于四种不同的感觉运动任务（运动执行、运动想象、主动观察和被动观察）和四种感觉运动振荡（Alpha、Beta、Low Beta 和 High Beta），每个模型，由年龄和性别控制。

结果

我们证明 KOA 和健康受试者之间的差异是频率特定的，因为大多数差异都在 beta 带宽范围内。此外，我们观察到 KOA 组的受试者具有显着更高的 ERD 和 ERS。这可能与大脑组织缺乏的程度以及随后由 KOA 引起的补偿尝试相关。

结论

我们的研究结果强化了这样一种观念，即患有 KOA 的受试者具有更高程度的大脑可塑性变化，这也可能与代偿和行为功能障碍的程度相关。