Corticobasal syndrome (CBS) is associated with 4-repeat tauopathy and/or Alzheimer's disease pathologies. To examine tau and amyloid-β (Aβ) deposits in CBS patients using positron emission tomography (PET). Eight CBS patients and three healthy individuals lacking amyloid pathology underwent PET with [¹¹C]PBB3 for tau imaging, and [¹¹C]AZD2184 for Aβ. Subcortical and cortical binding of [¹¹C]PBB3 was compared between Aβ(–) and Aβ(+) CBS patients and reference group. Postmortem analysis was done in one CBS patient. Three CBS patients were considered Aβ(+). Total binding was higher in all patients compared to the reference group. Similar regional binding profiles of [¹¹C]PBB3 in Aβ(+) and Aβ(–) CBS patients were found. Elevated [¹¹C]PBB3 binding in pallidum was observed in all CBS patients. Cortical [¹¹C]PBB3 binding was higher in Aβ(+) compared to Aβ(–) patients. Postmortem analysis of a CBS patient revealed corticobasal degeneration neuropathology and [¹¹C]PBB3 autofluorescence in some tau-positive structures. [¹¹C]PBB3 is elevated in CBS patients with binding in relevant areas capturing some, but not all, 4-repeat tauopathy in CBS.

中文翻译：

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[11C]PBB3 在 Aβ(–) 或 Aβ(+) 皮质基底节综合征中的结合

皮质基底节综合征 (CBS) 与 4 次重复 tau 病和/或阿尔茨海默氏病病理相关。使用正电子发射断层扫描 (PET) 检查 CBS 患者的 tau 和淀粉样蛋白-β (Aβ) 沉积物。八名 CBS 患者和三名缺乏淀粉样蛋白病理学的健康个体接受了 PET，其中 [ ¹¹ C]PBB3 用于 tau 成像，[ ¹¹ C]AZD2184 用于 Aβ。[ ¹¹ C]PBB3 的皮层下和皮层结合在 Aβ(–) 和 Aβ(+) CBS 患者与参照组之间进行了比较。对一名 CBS 患者进行了尸检分析。三名 CBS 患者被认为是 Aβ (+)。与参照组相比，所有患者的总结合均较高。在 Aβ(+) 和 Aβ(–) CBS 患者中发现了[ ^{11 C]PBB3 的相似区域结合谱。}升高 [在所有 CBS 患者中观察到^{11 C]PBB3 与苍白球的结合。}与 Aβ(–) 患者相比，Aβ(+) 患者的皮质 [ ^{11 C]PBB3 结合更高。}对一名 CBS 患者的尸检分析显示皮质基底节变性神经病理学和某些 tau 阳性结构中的 [ ¹¹ C]PBB3 自发荧光。[ ¹¹ C]PBB3 在 CBS 患者中升高，相关区域的结合捕获 CBS 中的一些但不是全部 4 重复 tau 病。