This study investigated the capability of phytoglycogen (PG) to improve the water-soluble amount and bioavailability of resveratrol (RES). RES and PG were incorporated through co-solvent mixing and spray-drying to form PG-RES solid dispersions. The soluble amount of RES of PG-RES solid dispersions reached 289.6 μg/mL at PG:RES ratio of 50:1, compared with 45.6 μg/mL for RES alone. X-ray powder diffraction and Fourier-transform infrared spectroscopy tests suggested a significant reduction of RES crystallinity in PG-RES solid dispersions and the formation of hydrogen bonds between RES and PG. Caco-2 monolayer permeation tests showed that, at low RES loading concentrations (15 and 30 μg/mL), PG-RES solid dispersions achieved greater permeation of RES (0.60 and 1.32 μg/well, respectively) than RES alone (0.32 and 0.90 μg/well, respectively). At an RES loading of 150 μg/mL, PG-RES solid dispersion realized RES permeation of 5.89 μg/well, suggesting the potential of PG in enhancing the bioavailability of RES.

本研究调查了植物糖原 (PG) 提高白藜芦醇 (RES) 水溶性量和生物利用度的能力。RES和PG通过共溶剂混合和喷雾干燥混合形成PG-RES固体分散体。当 PG:RES 比例为 50:1 时，PG-RES 固体分散体的 RES 可溶量达到 289.6 μg/mL，而单独的 RES 为 45.6 μg/mL。X射线粉末衍射和傅里叶变换红外光谱测试表明，PG-RES固体分散体中RES结晶度显着降低，RES和PG之间形成氢键。Caco-2 单层渗透测试表明，在低 RES 负载浓度（15 和 30 μg/mL）下，PG-RES 固体分散体比单独的 RES（0.32 和 0.90 μg/孔）实现了更高的 RES 渗透（分别为 0.60 和 1.32 μg/孔）。分别为μg/孔）。在RES负载量为150 μg/mL时，PG-RES固体分散体实现了5.89 μg/孔的RES渗透，表明PG具有增强RES生物利用度的潜力。