In this autobiographical article, I reflect on my Swedish background. Then I discuss endogenous DNA alterations and the base excision repair pathway and alternative repair strategies for some unusual DNA lesions. Endogenous DNA damage, such as loss of purine bases and cytosine deamination, is proposed as a major source of cancer-causing mutations.

中文翻译：

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DNA 脆弱性与修复：一些个人回忆

在这篇自传文章中，我反思了我的瑞典背景。然后我讨论内源性 DNA 改变和碱基切除修复途径以及一些不寻常 DNA 损伤的替代修复策略。内源性 DNA 损伤，例如嘌呤碱基的丢失和胞嘧啶脱氨，被认为是致癌突变的主要来源。