Polyethersulfone (PES) blended with glycopeptide Vancomycin was fabricated via phase inversion method. The fabricated membranes were characterized by scanning electron microscopy (SEM), fourier transform infrared spectroscopy (FTIR), contact angle (CA) and optical profilometry. The PES/Vancomycin membranes showed a notable increase in hydrophilicity, porosity, pore size, antibacterial activity and water flux in comparison with pristine membranes. The changes are due to the hydrophilic nature of Vancomycin molecules and ability to form hydrogen bond quickly. The surface hydrophilicity of PES/Vancomycin membranes decreased up to 48° with increase in surface roughness (R_a), that is, 0.347 μm, thus increasing the water flux of PES/Vancomycin membranes up to 340 L/m². h. The bovine serum albumin (BSA) rejection decreases, that is, pristine 70.9% to PES/Vancomycin 26% and BSA flux increases at constant ionic strength (0.1) and above the isoelectric point (IEP) of the BSA. Under these conditions, electrostatic interactions are expected to be minimum between protein and the membrane surfaces.

中文翻译：

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抗菌 PES/万古霉素超滤膜，具有增强的水通量和低 BSA 截留率

采用相转化法制备了与糖肽万古霉素共混的聚醚砜（PES）。通过扫描电子显微镜（SEM）、傅里叶变换红外光谱（FTIR）、接触角（CA）和光学轮廓测定法对制备的膜进行了表征。与原始膜相比，PES/万古霉素膜的亲水性、孔隙率、孔径、抗菌活性和水通量显着增加。这些变化是由于万古霉素分子的亲水性和快速形成氢键的能力造成的。_{PES/万古霉素膜的表面亲水性随着表面粗糙度(R a} )即0.347 μm的增加而降低达48° ，从而使PES/万古霉素膜的水通量增加至340 L/m ²。H。牛血清白蛋白 (BSA) 排斥率降低，即从原始的 70.9% 降至 PES/万古霉素 26%，并且在恒定离子强度 (0.1) 和高于 BSA 等电点 (IEP) 时，BSA 通量增加。在这些条件下，蛋白质和膜表面之间的静电相互作用预计最小。