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Role of Stereotactic Radiosurgery in Skull Base Paragangliomas - A Narrative Review.
Neurology India ( IF 2.7 ) Pub Date : 2023-04-08 , DOI: 10.4103/0028-3886.373640
Kanwaljeet Garg 1 , Manmohan Singh 1
Affiliation  

Skull base paragangliomas, also known as glomus tumors, are grouped as glomus jugulare or glomus tympanicum. Paragangliomas are rare tumors, with an estimated incidence of 1 case per million persons. They occur more commonly in females and are more common in the fifth or sixth decade of life. Management of these tumors traditionally involved surgical excision. However, surgical excision can result in high complication rates, particularly cranial nerve palsies. Stereotactic radiosurgery has been shown to yield tumor control rates of more than 90%. A recent meta-analysis reported improvement in neurological status in 48.7% of cases, while it stabilized in 39.3% of patients. Transient deficits such as headache, nausea, vomiting, and hemifacial spasm developed following SRS in 5.8% of patients, while 2.1% of patients developed permanent deficits. There is no difference in the rate of tumor control between different radiosurgery techniques. Dose-fractionated SRS can be used for large tumors to decrease the risk of radiation-induced complications.

中文翻译:

立体定向放射外科在颅底副神经节瘤中的作用 - 叙述性回顾。

颅底副神经节瘤,也称为血管球瘤,分为颈静脉球或鼓室球。副神经节瘤是一种罕见的肿瘤,估计发病率为每百万人 1 例。它们更常见于女性,并且在生命的第五或第六个十年中更常见。这些肿瘤的治疗传统上涉及手术切除。然而,手术切除会导致高并发症发生率,尤其是颅神经麻痹。立体定向放射外科已被证明可产生超过 90% 的肿瘤控制率。最近的一项荟萃​​分析报告称,48.7% 的病例神经系统状态有所改善,而 39.3% 的患者则稳定下来。5.8% 的患者在 SRS 后出现头痛、恶心、呕吐和面肌痉挛等短暂性缺陷,而 2.1% 的患者出现永久性缺陷。不同放射外科技术之间的肿瘤控制率没有差异。剂量分次 SRS 可用于大肿瘤,以降低辐射引起的并发症的风险。
更新日期:2023-04-08
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