ABSTRACT

Besides being known by food and perfume industries, vanillin has also important pharmacological properties such as anti-inflammatory and antibacterial activities. The use of magnetic nanoparticles as carriers for a vanillin delivery system is a way to explore its benefits in human beings. In this paper, poly(lactic-co-glycolic acid) (PLGA) nanoparticles stabilized by poly(vinyl alcohol) (PVA) and containing magnetic CoFe₂O₄ and vanillin have been prepared using a double emulsion-solvent evaporation method. The morphology, particle size, structure, and surface properties of the nanoparticles were investigated by transmission electron microscopy, zeta-potential measurements, X-ray diffractometry, Fourier transform infrared spectroscopy, magnetic hysteresis loops, and thermogravimetric analysis. The spherical nanoparticles presented negative charge, with zeta-potential values ranging from −9.15 to −5.64 mV, high thermal stability, superparamagnetic properties, and excellent encapsulation of the vanillin (around 80%). Accordingly, such PLGA/PVA nanoparticles encapsulating vanillin and CoFe₂O₄ exhibited the desired features to suggest their potential use as drug delivery systems.

摘要

除了为食品和香水行业所熟知外，香草醛还具有重要的药理特性，例如抗炎和抗菌活性。使用磁性纳米粒子作为香兰素递送系统的载体是探索其对人类益处的一种方式。在本文中，聚（乳酸 - 乙醇酸共聚物）（PLGA）纳米颗粒由聚（乙烯醇）（PVA）稳定并含有磁性 CoFe ₂ O ₄和香兰素是使用双乳液-溶剂蒸发法制备的。通过透射电子显微镜、zeta 电位测量、X 射线衍射、傅里叶变换红外光谱、磁滞回线和热重分析研究纳米粒子的形态、粒径、结构和表面性质。球形纳米颗粒呈现负电荷，zeta 电位值范围为 -9.15 至 -5.64 mV，具有高热稳定性、超顺磁性和出色的香草醛包封性（约 80%）。_{因此，这种包裹香草醛和 CoFe 2} O ₄的 PLGA/PVA 纳米颗粒表现出所需的特征，表明它们可用作药物递送系统。