Excessive aggression in children and youth can lead to impairments in family, social or academic functioning. The aim of the present study was to review the evidence on the effectiveness of nutritional supplements in reducing excessive hetero-aggression in children and youth (up to 18 years). The Cochrane Library, EMBASE, MEDLINE, ProQuest Dissertations & Theses, PsycINFO, and PubMed data bases were searched for relevant studies. Altogether, 22 studies met inclusion criteria; 13 investigated the effect of macronutrients (fatty acids and amino acids), 6 studies investigated the effect of micronutrients (vitamins and minerals), while 3 studies investigated a combination of macro- and micronutrients. Out of the 22 studies, 7 reported a beneficial effect of nutritional supplementation (vitamins and minerals, essential fatty acids, or a certain combination of these); eight studies did not report a significant beneficial effect of nutritional supplementation (essential fatty acids, vitamin D, and L-tryptophan); while 7 studies reported mixed effects (vitamin B6, essential fatty acids alone and in combination with vitamins and minerals, and carnitine). The results overall suggest that there may be a role for broad-range vitamin and mineral supplements in the treatment of hetero-aggression in youth and children, while the evidence for single-nutrient supplements is quite ambiguous.

儿童和青少年过度攻击会导致家庭、社会或学业功能受损。本研究的目的是审查营养补充剂在减少儿童和青少年（18 岁以下）过度异性攻击方面有效性的证据。在 Cochrane Library、EMBASE、MEDLINE、ProQuest Dissertations & Theses、PsycINFO 和 PubMed 数据库中搜索了相关研究。总共有 22 项研究符合纳入标准；13 项研究调查了常量营养素（脂肪酸和氨基酸）的影响，6 项研究调查了微量营养素（维生素和矿物质）的影响，而 3 项研究调查了常量营养素和微量营养素的组合。在 22 项研究中，有 7 项报告了营养补充的有益效果（维生素和矿物质、必需脂肪酸或这些的特定组合）；八项研究未报告营养补充剂（必需脂肪酸、维生素 D 和 L-色氨酸）的显着有益效果；而 7 项研究报告了混合效应（维生素 B6、单独的必需脂肪酸以及与维生素和矿物质的组合，以及肉毒碱）。结果总体表明，广泛的维生素和矿物质补充剂可能在治疗青少年和儿童的异类攻击方面发挥作用，而单一营养素补充剂的证据则相当模糊。