Objectives: To analyze the published evidence for the use of fallopian tube brush cytology for the early detection of extrauterine serous gynecological cancer. Methods: We systematically searched the literature and, additionally, cross checked on the bibliographies of selected articles. The inclusion criteria involved studies assessing the utility of fallopian tube brush cytology and its applications in the diagnosis, screening or follow up of extrauterine serous gynecological cancer. Results: The search strategy resulted in 21 abstracts or full-text articles, 5 of which met the inclusion criteria. The year of publication ranged from 2016 to 2022, and a total of 193 fallopian tube samples were investigated. Cytobrush, Tubebrush©, and Cytuity™ were used to obtain salpingeal samples for liquid-based cytology evaluation. Conclusions: Our findings indicate that, at present, there is a lack of satisfying evidence-based data in the literature which would support the implementation of fallopian tube brush cytology as an adjunctive tool for early detection of extrauterine serous gynecological cancer. Thus, we believe that there is need for well-designed clinical studies to assess the effectiveness and diagnostic accuracy of the method as well as to validate the cytological criteria for the diagnosis and prediction of gynecological malignancies.


中文翻译：

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输卵管细胞学在宫外浆液性妇科恶性肿瘤早期检测中的应用：叙述性文献综述”

目的：分析已发表的使用输卵管刷细胞学检查早期发现宫外浆液性妇科癌症的证据。方法：我们系统地检索了文献，并对选定文章的参考书目进行了交叉核对。纳入标准涉及评估输卵管刷细胞学的实用性及其在宫外浆液性妇科癌症的诊断、筛查或随访中的应用的研究。结果：检索策略得出 21 篇摘要或全文文章，其中 5 篇符合纳入标准。发表年份为2016年至2022年，共调查了193个输卵管样本。使用 Cytobrush、Tubebrush© 和 Cytuity™ 获取输卵管样本以进行液基细胞学评估。结论：我们的研究结果表明，目前文献中缺乏令人满意的循证数据来支持输卵管刷细胞学检查作为早期检测宫外浆液性妇科癌症的辅助工具。因此，我们认为需要精心设计的临床研究来评估该方法的有效性和诊断准确性，并验证妇科恶性肿瘤诊断和预测的细胞学标准。