Skin is composed of major layers, namely a superficial epidermis and a deeper dermis. The color of skin is influenced by a number of pigments, including melanin, which is produced by cells called melanocytes. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal. A number of more noticeable disorders, namely albinism and vitiligo, affect the appearance of the skin and its accessory organs. Vitiligo is associated with significant psycho-social morbidity and a major effect on quality of life. Topical steroids, calcineurin inhibitors, phototherapy and surgery are the most common treatments for melanoma. However, there are many patients who do not respond to any of these modalities. The transplantation of cultured or non-cultured melanocyte is the most important treatment for hypopigmentory disorders. This study aims at reviewing the history of melanocyte cultivation, and evaluating the effectiveness of transplantation of cultured cells. For this purpose, the authors examined the initial process of isolation, characterization, and transplantation of epidermal cells. This review, thus, summarizes the current understanding of the cutaneous pigmentary system from the start of synthesis in the pigment cells, along with the response of repigmentation. During the production of melanin, melanosomes are transferred to neighboring keratinocyte in order to form perinuclear melanin caps. The objective of this review is to analyze the melanocytes transplantation in the last century to date, and explore the methods epidermal cells can increase pigmentation in hypo-pigmented areas in skin disorders. Moreover, the focus is on the story of the melanocyte back to 1950s. In addition, prior systemic therapy was associated with a significant increase, based on combined additional therapy, achieving desired results and improved outcomes. Despite the short study of a long way of melanocyte assessment and following up patient treatment, results of the all reports confirmed the efficacy of the method used in the treatment of stable vitiligo patients, who did not respond to the common algorithms of non-invasive treatments.

皮肤由主要层组成，即浅表皮和深层真皮。皮肤的颜色受许多色素的影响，包括黑色素，黑色素是由称为黑素细胞的细胞产生的。大多数皮肤病是相对良性的，但包括黑色素瘤在内的少数皮肤病可能是致命的。许多更明显的疾病，即白化病和白斑病，会影响皮肤及其附属器官的外观。白癜风与显着的心理-社会发病率和对生活质量的重大影响有关。局部类固醇、神经钙蛋白抑制剂、光疗和手术是黑色素瘤最常见的治疗方法。然而，有许多患者对这些方式中的任何一种都没有反应。培养或未培养的黑素细胞移植是治疗色素减退症最重要的方法。本研究旨在回顾黑素细胞培养的历史，评价培养细胞移植的有效性。为此，作者检查了表皮细胞分离、表征和移植的初始过程。因此，这篇综述总结了目前对皮肤色素系统从色素细胞合成开始的理解，以及对色素沉着反应的理解。在黑色素的产生过程中，黑色素体被转移到邻近的角质形成细胞以形成核周黑色素帽。本综述的目的是分析上个世纪至今的黑素细胞移植，探索表皮细胞增加皮肤病色素减退区色素沉着的方法。而且，重点是 1950 年代黑色素细胞的故事。此外，在联合额外治疗的基础上，先前的全身治疗与显着增加相关，实现了预期的结果和改善的结果。尽管黑素细胞评估和后续患者治疗的长期研究很短，但所有报告的结果都证实了该方法用于治疗稳定的白癜风患者的有效性，这些患者对非侵入性治疗的常用算法没有反应.