Background. Pulmonary sarcoidosis predominantly affects the upper lung zones but sometimes affects the lower lung zones. We hypothesised that patients with lower lung zone-dominant sarcoidosis had lower baseline forced vital capacity, progressive restrictive lung function decline, and higher long-term mortality. Methods. We retrospectively reviewed clinical data including the pulmonary function tests of 108 consecutive patients with pulmonary sarcoidosis pathologically confirmed by lung and/or mediastinal lymph node biopsy from 2004 to 2014 from our database. Results. Eleven patients (10.2%) with lower lung zone-dominant sarcoidosis were compared with 97 patients with nonlower lung zone-dominant sarcoidosis. The median age of the patients with lower dominance was significantly older (71 vs. 56, ). The patient with lower dominance had a significantly lower baseline percent forced vital capacity (FVC) (96.0% vs. 103%, ). The annual change in FVC was −112 mL in those with lower dominance vs. 0 mL in nonlower dominance (). Fatal acute deterioration was observed in three patients (27%) in the lower dominant group. Overall survival in the lower dominant group was significantly worse. Conclusions. Patients with lower lung zone-dominant sarcoidosis had an older age and lower baseline FVC with disease progression and acute deterioration associated with higher long-term mortality.

中文翻译：

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下肺为主型结节病患者预后差且死亡率低

背景。肺结节病主要影响上肺区，但有时影响下肺区。我们假设下肺区为主的结节病患者基线用力肺活量较低、进行性限制性肺功能下降和长期死亡率较高。方法。我们回顾性回顾了 2004 年至 2014 年数据库中 108 例经肺和/或纵隔淋巴结活检病理证实的肺结节病患者的肺功能检查等临床数据。结果. 将 11 名 (10.2%) 下肺区为主型结节病患者与 97 名非下肺区为主型结节病患者进行比较。支配力较低的患者的中位年龄明显较大（71 岁对 56 岁，). 支配力较低的患者的基线百分比用力肺活量 (FVC) 显着较低（96.0% 对 103%，). FVC 的年度变化在具有较低优势的人群中为 -112 mL，而在非低优势人群中为 0 mL（). 在较低优势组的三名患者 (27%) 中观察到致命的急性恶化。较低优势组的总体生存率明显更差。结论。下肺区为主的结节病患者年龄较大，基线 FVC 较低，疾病进展和急性恶化与较高的长期死亡率相关。