Neural oscillations have been categorized into various frequency bands that are mechanistically associated with different cognitive functions. Specifically, the gamma band frequency is widely implicated to be involved in a wide range of cognitive processes. As such, decreased gamma oscillation has been associated with cognitive declines in neurological diseases, such as memory dysfunction in Alzheimer’s disease (AD). Recently, studies have attempted to artificially induce gamma oscillations by using 40 Hz sensory entrainment stimulation. These studies reported attenuation of amyloid load, hyper-phosphorylation of tau protein, and improvement in overall cognition in both AD patients and mouse models. In this review, we discuss the advancements in the use of sensory stimulation in animal models of AD and as a therapeutic strategy in AD patients. We also discuss future opportunities, as well as challenges, for using such strategies in other neurodegenerative and neuropsychiatric diseases.

中文翻译：

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用于神经退行性疾病认知改善的伽马感觉夹带：未来的机遇和挑战

神经振荡已被分类为与不同认知功能机械相关的各种频带。具体而言，伽马波段频率广泛涉及广泛的认知过程。因此，减少的伽马振荡与神经系统疾病的认知能力下降有关，例如阿尔茨海默病 (AD) 的记忆功能障碍。最近，研究试图通过使用 40 Hz 感官夹带刺激来人工诱导伽马振荡。这些研究报告了 AD 患者和小鼠模型中淀粉样蛋白负荷的减弱、tau 蛋白的过度磷酸化以及整体认知的改善。在这篇综述中，我们讨论了在 AD 动物模型中使用感觉刺激的进展以及作为 AD 患者的治疗策略。