ABSTRACT

Di(2-ethylhexyl) phthalate (DEHP) is an extensively used plasticizer and being non-covalently bound to plastics it leaches out into the environment. This addresses a grave concern on its potential human exposure and subsequent deleterious effects. The ameliorative potential of Spirulina (Arthrospira platensis) against DEHP-induced toxicity was assessed in rats. Group I was control. Group II and III, were exposed to a low dose of DEHP (125 mg/kg), and Group IV and V were exposed to a high dose of DEHP (250 mg/kg). Group III and V were treated with spirulina orally (1000 mg/Kg) for 3 weeks. Exposure to DEHP elicited marked oxidative stress and associated DNA damage in a dose-dependent manner. The hepatic expression of p53 was also significantly suppressed. Liver and kidney function tests showed marked alterations. Treatment with spirulina efficaciously reversed the adverse effects. Thus, these findings offer a nutritional intervention of spirulina to combat the environmental exposure to plasticizers.

摘要

邻苯二甲酸二（2-乙基己基）酯 (DEHP) 是一种广泛使用的增塑剂，与塑料非共价键结合后会渗出到环境中。这解决了人们对其潜在的人类暴露和随后的有害影响的严重担忧。在大鼠中评估了螺旋藻（Arthrospira platensis）对 DEHP 诱导的毒性的改善潜力。第一组是控制。II 组和 III 组暴露于低剂量的 DEHP（125 mg/kg），IV 组和 V 组暴露于高剂量的 DEHP（250 mg/kg）。第 III 组和第 V 组口服螺旋藻 (1000 mg/Kg) 治疗 3 周。暴露于 DEHP 会以剂量依赖的方式引起显着的氧化应激和相关的 DNA 损伤。p53 的肝脏表达也被显着抑制。肝肾功能检查显示明显改变。螺旋藻治疗有效地逆转了不良反应。因此，这些发现提供了螺旋藻的营养干预，以对抗增塑剂的环境暴露。