Here, we examined mechanisms that affect retrograde memory in amnestic mild cognitive impairment (a-MCI) as a function of longitudinal clinical outcome. 8 a-MCI who converted to Alzheimer's dementia (AD) during the subsequent 3-year follow-up (converter a-MCI) and 10 a-MCI who remained clinically stable during the same period (stable a-MCI) were compared at the baseline evaluation (i.e., when they were diagnosed as a-MCI) using a remote memory questionnaire for public events that allows disentangling the differential contribution of storage and retrieval mechanisms to performance accuracy. Results suggest that deficits in remote memory are primarily explained by impaired retrieval abilities in stable a-MCI and by impaired storage in converter-to-AD a-MCI. This distinction between retrograde amnesia due to defective trace utilisation in stable a-MCI and trace storage in converter a-MCI is consistent with the temporal unfolding of declining anterograde memory over the course of disease progression to AD.

中文翻译：

---

探索影响遗忘性轻度认知障碍中公共事件逆行记忆的机制：纵向更新

在这里，我们研究了影响遗忘性轻度认知障碍（a-MCI）逆行记忆的机制作为纵向临床结果的函数。在随后的 3 年随访中，对 8 名转变为阿尔茨海默氏痴呆 (AD) 的 a-MCI（转变者 a-MCI）和 10 名在同一时期保持临床稳定的 a-MCI（稳定 a-MCI）进行了比较。使用公共事件的远程记忆调查问卷进行基线评估（即，当他们被诊断为 a-MCI 时），可以理清存储和检索机制对性能准确性的不同贡献。结果表明，远程记忆缺陷主要是由于稳定 a-MCI 的检索能力受损以及 AD a-MCI 转换器的存储能力受损所致。由于稳定a-MCI中的痕迹利用缺陷和转换器a-MCI中的痕迹存储而导致的逆行性遗忘之间的区别与疾病进展为AD过程中顺行性记忆衰退的时间展开一致。