Background Cervical cancer burden and prevalence of precursor lesions is unknown among young women living with HIV in high prevalence settings. Current cervical cancer screening guidelines in resource-limited settings with high HIV prevalence typically exclude adolescents and young women. After observing two cases of advanced cervical cancer among young women with perinatally acquired HIV, a pilot screening programme was established in Botswana. Objectives To compare the prevalence of cervical abnormalities in young women with perinatally acquired HIV with women aged 30-49 years, regardless of HIV status. Method We conducted a cross-sectional study of 30-49-year-old women who had visual inspection with acetic acid screening through the Botswana public sector programme, and youth (aged 15-24 years) with perinatally acquired HIV, at a single referral site between 2016 and 2018. We describe the prevalence of cervical abnormalities in each group as well as the crude prevalence ratio. Results The prevalence of cervical abnormalities in women 30-49 years of age was 10.9% (95% confidence interval [CI]: 10.4, 11.4), and 10.1% (95% CI: 4.7, 18.3) for youth. The crude prevalence ratio was 1.07 (95% CI: 0.58, 2.01). Conclusion Inclusion of youth living with HIV in cervical cancer screening services should be considered in settings with a high prevalence of HIV and cervical cancer.

中文翻译：

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宫颈异常的患病率：博茨瓦纳围产期感染艾滋病毒的青年与老年妇女的比较。

背景 在高流行环境中感染 HIV 的年轻女性中，宫颈癌负担和前期病变的流行尚不清楚。目前在资源有限且 HIV 感染率高的环境中进行的宫颈癌筛查指南通常将青少年和年轻女性排除在外。在观察到两例围产期感染 HIV 的年轻女性患上晚期宫颈癌后，博茨瓦纳建立了试点筛查计划。目的 比较围产期感染 HIV 的年轻女性与 30-49 岁女性的宫颈异常患病率，无论 HIV 状态如何。方 在 2016 年至 2018 年之间的单个转诊站点。我们描述了每组宫颈异常的患病率以及粗患病率。结果 30-49 岁女性宫颈异常的患病率为 10.9%（95% 置信区间 [CI]：10.4, 11.4），青年为 10.1%（95% CI：4.7, 18.3）。粗患病率为 1.07（95% CI：0.58，2.01）。结论 在 HIV 和宫颈癌高发环境中，应考虑将感染 HIV 的青年纳入宫颈癌筛查服务。3) 青年。粗患病率为 1.07（95% CI：0.58，2.01）。结论 在 HIV 和宫颈癌高发环境中，应考虑将感染 HIV 的青年纳入宫颈癌筛查服务。3) 青年。粗患病率为 1.07（95% CI：0.58，2.01）。结论 在 HIV 和宫颈癌高发环境中，应考虑将感染 HIV 的青年纳入宫颈癌筛查服务。