Long-term memory (LTM) formation is dependent on neurochemical changes that guarantee that a recently formed memory (short-term memory [STM]) remains in the specific neural circuitry via the consolidation process. The persistence of recognition memory has been evidenced by using behavioral tagging in young adult rats, but it has not been effective on aging. Here, we investigated the effects of treatment with a standardized extract of Ginkgo biloba (EGb) associated with novelty on the consolidation of object location memory (OLM) and its persistence after weak training of spatial object preference in young adult and aged rats. The object location task used in this study included two habituation sessions, training sessions associated or not associated with EGb treatment and contextual novelty, and short-term or long-term retention testing sessions. Altogether, our data showed that treatment with EGb associated with novelty close to the time of encoding resulted in STM that lasted for 1 h and persisted for 24 h for both young adult and aged rats. In aged rats, the cooperative mechanisms induced robust long-term OLM. Our findings support and extend our knowledge about recognition memory in aged rats and the modulating effects of EGb treatment and contextual novelty on the persistence of memory.

中文翻译：

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银杏叶标准化提取物治疗及对大鼠空间识别记忆弱编码的新颖性

长期记忆 (LTM) 的形成取决于神经化学变化，这些变化保证最近形成的记忆（短期记忆 [STM]）通过巩固过程保留在特定的神经回路中。通过在年轻的成年大鼠中使用行为标记，已经证明了识别记忆的持久性，但它对衰老没有效果。在这里，我们研究了用标准化的银杏叶提取物治疗的效果(EGb) 与对象位置记忆 (OLM) 巩固的新颖性及其在年轻成年和老年大鼠空间对象偏好弱训练后的持久性相关。本研究中使用的对象定位任务包括两个习惯化课程、与 EGb 治疗和上下文新颖性相关或不相关的培训课程，以及短期或长期保留测试课程。总而言之，我们的数据表明，在接近编码时间的时候，用与新颖性相关的 EGb 治疗导致 STM 持续 1 小时，并持续 24 小时，对于年轻的成年大鼠和老年大鼠。在老年大鼠中，合作机制诱导了强大的长期 OLM。我们的研究结果支持并扩展了我们对老年大鼠识别记忆以及 EGb 治疗和情境新颖性对记忆持久性的调节作用的认识。