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5-HT and S100β values in evaluating severity of cognitive impairment after traumatic brain injury
Folia Neuropathologica ( IF 2 ) Pub Date : 2023-02-16 , DOI: 10.5114/fn.2023.125119 Guan Jin 1 , Yanhao Yang 1 , Feng Bi 1 , Mingyan Yang 1 , Yinhua Ma 2
Folia Neuropathologica ( IF 2 ) Pub Date : 2023-02-16 , DOI: 10.5114/fn.2023.125119 Guan Jin 1 , Yanhao Yang 1 , Feng Bi 1 , Mingyan Yang 1 , Yinhua Ma 2
Affiliation
Introduction:
The aim of the study was to investigate the relationship between serum serotonin (5-HT) and central nervous system specific protein S100b application value in evaluating the severity of cognitive impairment after traumatic brain injury (TBI).
Material and methods:
102 patients with TBI treated in Jilin Neuropsychiatric Hospital from June 2018 to October 2020 were selected. According to Montreal Cognitive Assessment (MoCA) scale, patients were tested for cognitive function from multiple levels, such as attention, executive function, memory, and language. Patients with cognitive impairment were included into study group (n = 64), and those without cognitive impairment were assigned to control group (n = 58). Serum 5-HT and S100b were compared between the two groups with b level. Serum 5-HT and S100b were analyzed by receiver operating characteristic curve (ROC), b application value judging cognitive impairment.
Results:
Serum 5-HT and S100b levels in the study group were significantly higher than those in the control group (p < 0.05). In serum 5-HT and S100b, there was a significant negative correlation with a MoCA score (r = –0.527, r = –0.436; p < 0.05, p < 0.05). Combined detection of serum 5-HT and S100b’s area under ROC curve (AUC) was 0.810 (95% CI: 0.742-0.936, p < 0.05), sensitivity was 0.842, and specificity was 0.813.
Conclusions:
Serum 5-HT and S100b levels are closely related to the cognitive function of TBI patients. Combined detection is helpful to improve the accuracy of predicting cognitive impairment.
中文翻译：
5-HT和S100β值评价颅脑损伤后认知功能障碍严重程度
【摘要】：
目的探讨血清5-羟色胺(5-HT)与中枢神经系统特异性蛋白S100b的关系在评估创伤性脑损伤(TBI)后认知障碍严重程度中的应用价值。
材料与方法：
选择2018年6月至2020年10月吉林省神经精神医院收治的102例TBI患者。根据蒙特利尔认知评估（MoCA）量表，从注意力、执行功能、记忆力和语言等多个层面对患者进行认知功能测试。认知障碍患者纳入研究组（n =64），无认知障碍患者纳入对照组（n= 58). 比较两组患者血清5-HT、S100b及b水平。血清5-HT和S100b通过受试者工作特征曲线（ROC）分析，b应用价值判断认知障碍。
结果：
研究组血清 5-HT 和 S100b 水平显着高于对照组（p < 0.05）。在血清 5-HT 和 S100b 中，与 MoCA 评分呈显着负相关（r = –0.527，r = –0.436；p < 0.05，p < 0.05）。联合检测血清 5-HT 和 S100b 的 ROC 曲线下面积（AUC）为 0.810（95% CI：0.742-0.936，p < 0.05），灵敏度为 0.842，特异性为 0.813。
结论：
血清5-HT和S100b水平与TBI患者的认知功能密切相关。联合检测有助于提高预测认知障碍的准确性。
更新日期：2023-02-16
The aim of the study was to investigate the relationship between serum serotonin (5-HT) and central nervous system specific protein S100b application value in evaluating the severity of cognitive impairment after traumatic brain injury (TBI).
Material and methods:
102 patients with TBI treated in Jilin Neuropsychiatric Hospital from June 2018 to October 2020 were selected. According to Montreal Cognitive Assessment (MoCA) scale, patients were tested for cognitive function from multiple levels, such as attention, executive function, memory, and language. Patients with cognitive impairment were included into study group (n = 64), and those without cognitive impairment were assigned to control group (n = 58). Serum 5-HT and S100b were compared between the two groups with b level. Serum 5-HT and S100b were analyzed by receiver operating characteristic curve (ROC), b application value judging cognitive impairment.
Results:
Serum 5-HT and S100b levels in the study group were significantly higher than those in the control group (p < 0.05). In serum 5-HT and S100b, there was a significant negative correlation with a MoCA score (r = –0.527, r = –0.436; p < 0.05, p < 0.05). Combined detection of serum 5-HT and S100b’s area under ROC curve (AUC) was 0.810 (95% CI: 0.742-0.936, p < 0.05), sensitivity was 0.842, and specificity was 0.813.
Conclusions:
Serum 5-HT and S100b levels are closely related to the cognitive function of TBI patients. Combined detection is helpful to improve the accuracy of predicting cognitive impairment.
中文翻译：
5-HT和S100β值评价颅脑损伤后认知功能障碍严重程度
【摘要】：
目的探讨血清5-羟色胺(5-HT)与中枢神经系统特异性蛋白S100b的关系在评估创伤性脑损伤(TBI)后认知障碍严重程度中的应用价值。
材料与方法：
选择2018年6月至2020年10月吉林省神经精神医院收治的102例TBI患者。根据蒙特利尔认知评估（MoCA）量表，从注意力、执行功能、记忆力和语言等多个层面对患者进行认知功能测试。认知障碍患者纳入研究组（n =64），无认知障碍患者纳入对照组（n= 58). 比较两组患者血清5-HT、S100b及b水平。血清5-HT和S100b通过受试者工作特征曲线（ROC）分析，b应用价值判断认知障碍。
结果：
研究组血清 5-HT 和 S100b 水平显着高于对照组（p < 0.05）。在血清 5-HT 和 S100b 中，与 MoCA 评分呈显着负相关（r = –0.527，r = –0.436；p < 0.05，p < 0.05）。联合检测血清 5-HT 和 S100b 的 ROC 曲线下面积（AUC）为 0.810（95% CI：0.742-0.936，p < 0.05），灵敏度为 0.842，特异性为 0.813。
结论：
血清5-HT和S100b水平与TBI患者的认知功能密切相关。联合检测有助于提高预测认知障碍的准确性。
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