Abstract

Saccadic eye movements are one of the sensitive and noninvasive methods to help monitor the cognitive course of mild cognitive impairment (MCI). The study aimed to evaluate both pro and anti-saccade longitudinally and the relationship between cognitive functions and eye movements in MCI subgroups and healthy controls (HCs) at a two-year follow-up. This study revealed that the anti-saccade anticipatory responses decreased in amnestic MCI (aMCI). Correct vertical pro-saccades increased in non-amnestic MCI (naMCI), while the express saccades decreased. Our study demonstrated that longer than two years of follow-up is necessary to monitor the course of MCI. Findings of the relationships between longitudinal changes of saccades and cognitive measurements demonstrated the usability of eye movements in evaluating the process of MCI.

摘要

眼跳运动是帮助监测轻度认知障碍（MCI）认知过程的敏感且无创的方法之一。该研究旨在在两年的随访中纵向评估支持眼跳和抗眼跳以及 MCI 亚组和健康对照 (HC) 认知功能和眼球运动之间的关系。这项研究表明，遗忘性MCI（aMCI）的抗眼跳预期反应降低。非遗忘性 MCI (naMCI) 中正确的垂直前眼跳增加，而快速眼跳减少。我们的研究表明，需要两年以上的随访来监测 MCI 的病程。眼跳纵向变化与认知测量之间关系的发现证明了眼动在评估 MCI 过程中的可用性。