Melanoma is a dangerous type of skin cancer sometimes treated with radiotherapy. However, it induces damage to the surrounding healthy tissue and possibly further away areas. Therefore, it is necessary to give a lower dose to the patient with targeted therapy. In this study, the radio-sensitising effect of gold-coated iron oxide nanoparticles on electron beam radiotherapy of a melanoma tumour with magnetic targeting in a mouse model was investigated. Gold-coated iron oxide nanoparticles were prepared in a steady procedure. The melanoma tumour model was induced in mice. Animals were divided into five groups: (1) normal; (2) melanoma; (3) gold-coated iron oxide nanoparticles alone; (4) electron beam radiotherapy; (5) electron beam radiotherapy plus gold-coated iron oxide nanoparticles. The magnet was placed on the tumour site for 2 h. The tumours were then exposed to 6 MeV electron beam radiotherapy for a dose of 8 Gy. Inductively coupled plasma optical emission spectrometry test, hematoxylin and eosin staining, and enzyme-linked immunosorbent assay blood test were also performed. Gold-coated iron oxide nanoparticles with magnetic targeting before electron beam radiotherapy reduced the growth of the tumour compared to the control group. Blood tests did not show any significant toxicity. Deposition of nanoparticles was more in the tumour and spleen tissue and to a lesser extent in the liver, kidney, and lung tissues. The synergistic effect of nanoparticles administered by the intraperitoneal route and then concentrated into the tumour area by application of an external permanent magnet, before delivery of the electron beam radiotherapy improved the overall cancer treatment outcome and prevented metal distribution side effects.

中文翻译：

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氧化铁-金纳米复合物对磁靶向体内黑色素瘤电子束治疗的放射增敏作用。

黑色素瘤是一种危险的皮肤癌，有时需要放疗。然而，它会对周围的健康组织和可能更远的区域造成损害。因此，有必要给予患者较低剂量的靶向治疗。在这项研究中，研究了金涂层氧化铁纳米粒子对小鼠模型中磁性靶向黑色素瘤电子束放射治疗的放射增敏作用。金包覆的氧化铁纳米颗粒是在一个稳定的过程中制备的。在小鼠中诱导黑色素瘤模型。动物分为五组：（1）正常；(2) 黑色素瘤；(3) 单独的金包覆氧化铁纳米颗粒；(4)电子束放射治疗；(5)电子束放疗加纳米氧化铁包金。将磁铁放在肿瘤部位 2 小时。然后将肿瘤暴露于 6 MeV 电子束放射治疗，剂量为 8 Gy。还进行了电感耦合等离子体发射光谱测试、苏木精和伊红染色以及酶联免疫吸附测定血液测试。与对照组相比，电子束放疗前具有磁性靶向的金包覆氧化铁纳米颗粒减少了肿瘤的生长。血液测试未显示任何显着毒性。纳米颗粒在肿瘤和脾脏组织中沉积较多，在肝脏、肾脏和肺组织中沉积较少。通过腹膜内途径给药的纳米粒子的协同作用，然后通过应用外部永磁体集中到肿瘤区域，