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How to counteract the lack of donor tissue in cardiac surgery? Initial experiences with a newly established homograft procurement program
Cell and Tissue Banking ( IF 1.5 ) Pub Date : 2023-04-25 , DOI: 10.1007/s10561-023-10087-z
Martin O Schmiady 1, 2, 3 , Ramadan Jashari 4 , Renato Lenherr 5 , Stefan Regenscheit 5 , Dave Hitendu 2, 3 , Martin Wendt 6 , Stefanie Schiess 6 , Martin Schweiger 2, 3 , Michael Hofmann 1 , Juri Sromicki 1 , Andreas Flammer 7 , Markus J Wilhelm 1 , Robert Cesnjevar 2, 3 , Thierry Carrel 1 , Paul R Vogt 1 , Carlos A Mestres 1
Affiliation  

Homograft heart valves may have significant advantages and are preferred for the repair of congenital valve malformations, especially in young women of childbearing age, athletes and in patients with active endocarditis. A growing problem, however, is the mismatch between tissue donation and the increasing demand. The aim of this paper is to describe the initiation process of a homograft procurement program to attenuate the shortage of organs. A comprehensive description of the infrastructure and procedural steps required to initiate a cardiac and vascular tissue donation program combined with a prospective follow-up of all homografts explanted at our institution. Between January 2020 and May 2022, 28 hearts and 12 pulmonary bifurcations were harvested at our institution and delivered to the European homograft bank. Twenty-seven valves (19 pulmonary valves, 8 aortic valves) were processed and allocated for implantation. The reasons for discarding a graft were either contamination (n = 14), or morphology (n = 13) or leaflet damage (n = 2). Five homografts (3 PV, 2 AV) have been cryopreserved and stored while awaiting allocation. One pulmonary homograft with a leaflet cut was retrieved by bicuspidization technique and awaits allocation, as a highly requested small diameter graft. The implementation of a tissue donation program in cooperation with a homograft bank can be achieved with reasonable additional efforts at a transplant center with an in-house cardiac surgery department. Challenging situations with a potential risk of tissue injury during procurement include re-operation, harvesting by a non-specialist surgeon and prior central cannulation for mechanical circulatory support.



中文翻译:

如何应对心脏手术中供体组织的缺乏?新建立的同种移植采购计划的初步经验

同种移植心脏瓣膜可能具有显着优势,是先天性瓣膜畸形修复的首选,特别是在育龄的年轻女性、运动员和活动性心内膜炎患者中。然而,一个日益严重的问题是组织捐赠与不断增长的需求之间的不匹配。本文的目的是描述同种移植采购计划的启动过程,以缓解器官短缺。全面描述启动心脏和血管组织捐赠计划所需的基础设施和程序步骤,并结合对我们机构移植的所有同种移植物的前瞻性随访。2020 年 1 月至 2022 年 5 月期间,我们机构采集了 28 颗心脏和 12 颗肺分叉,并交付至欧洲同种移植库。处理并分配了 27 个瓣膜(19 个肺动脉瓣,8 个主动脉瓣)用于植入。丢弃移植物的原因是污染(n  = 14),或形态学 ( n  = 13) 或小叶损伤 ( n  = 2)。五个同种移植物(3 个 PV,2 个 AV)在等待分配时被冷冻保存。一个带有小叶切口的肺部同种移植物通过二尖瓣化技术回收并等待分配,作为一种高度要求的小直径移植物。与同种移植库合作实施组织捐赠计划可以在具有内部心脏外科部门的移植中心通过合理的额外努力来实现。在采购过程中具有潜在组织损伤风险的挑战性情况包括再次手术、由非专业外科医生进行采集以及为机械循环支持预先进行中央插管。

更新日期:2023-04-26
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