The recombination of V, D, and J immunoglobulin (IG) gene segments leads to many variations in the amino acids (AAs) encoded at that site, the complementarity determining region-3 (CDR3). Thus, cancer patients may have varying degrees of CDR3 AA binding specificity for cancer proteases, for example, matrix metalloproteinase 2 (MMP2). MMP2 in breast cancer has been found to contribute to metastasis and is used as a marker for tumor staging. Thus, this report evaluated the tumor resident, patient specific IG CDR3 binding affinities to cancer proteases to test the hypothesis that greater binding affinities would be associated with a better outcome.

中文翻译：

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一项生物信息学评估表明乳腺癌患者的免疫球蛋白 CDR3-MMP2 结合具有更好的结果。

V、D 和 J 免疫球蛋白 (IG) 基因片段的重组导致在该位点编码的氨基酸 (AA) 发生许多变化，即互补决定区 3 (CDR3)。因此，癌症患者可能对癌症蛋白酶（例如基质金属蛋白酶 2 (MMP2)）具有不同程度的 CDR3 AA 结合特异性。已发现乳腺癌中的 MMP2 有助于转移，并用作肿瘤分期的标志物。因此，该报告评估了肿瘤驻留的患者特异性 IG CDR3 对癌症蛋白酶的结合亲和力，以检验更大的结合亲和力与更好的结果相关的假设。