Purpose of Review

To perform a systematic review and meta-analysis of the prevalence of diabetes in patients with hyperuricemia and gout.

Recent Findings

Previous studies have confirmed that hyperuricemia and gout are associated with an increased risk of diabetes. A previous meta-analysis indicated that the prevalence of diabetes in patients with gout is 16%.

Summary

Thirty-eight studies (458,256 patients) were included in the meta-analysis. The combined prevalence of diabetes among patients with hyperuricemia and gout were 19.10% (95% confidence interval [CI]: 17.60-20.60; I² = 99.40%) and 16.70% (95% CI: 15.10-18.30; I² = 99.30%), respectively. Patients from North America showed a higher prevalence of diabetes (hyperuricemia: 20.70% [95% CI: 16.80-24.60], gout: 20.70% [95% CI: 16.80-24.60]) than those from other continents. Older patients with hyperuricemia and those using diuretics showed a higher prevalence of diabetes than younger patients and those who were not using diuretics. Studies with a small sample size, case-control design, and low quality score had a higher prevalence of diabetes than studies with a large sample size, other designs, and a high quality score. The prevalence of diabetes among patients with hyperuricemia and gout is high. Controlling plasma glucose and uric acid levels of patients with hyperuricemia and gout is critical for the prevention of diabetes.

中文翻译：

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高尿酸血症和痛风患者的糖尿病患病率：一项系统评价和荟萃分析

审查目的

对高尿酸血症和痛风患者的糖尿病患病率进行系统评价和荟萃分析。

最近的发现

此前的研究已经证实，高尿酸血症和痛风与糖尿病风险增加有关。之前的一项荟萃​​分析表明，痛风患者中糖尿病的患病率为 16%。

概括

荟萃分析包括 38 项研究（458,256 名患者）。高尿酸血症和痛风患者的糖尿病合并患病率分别为 19.10%（95% 置信区间 [CI]：17.60-20.60；I ²  = 99.40%）和 16.70%（95% CI：15.10-18.30；I ² = 99.30%),分别。北美患者的糖尿病患病率（高尿酸血症：20.70% [95% CI：16.80-24.60]，痛风：20.70% [95% CI：16.80-24.60]）高于其他大陆的患者。老年高尿酸血症患者和使用利尿剂的患者比年轻患者和未使用利尿剂的患者糖尿病患病率更高。样本量小、病例对照设计和质量评分低的研究的糖尿病患病率高于样本量大、其他设计和质量评分高的研究。高尿酸血症和痛风患者中糖尿病的患病率很高。控制高尿酸血症和痛风患者的血糖和尿酸水平对于预防糖尿病至关重要。