Chronic pain is poorly treated with many developing disabling comorbidities such as anxiety, depression and insomnia. Considerable evidence supports the idea that pain and anxiodepressive disorders share a common neurobiology and can mutually reinforce, which has significant long-term implications as the development of comorbidities leads to poorer treatment outcomes for both pain and mood disorders. This article will review recent advances in the understanding of the circuit basis for comorbidities in chronic pain.

中文翻译：

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慢性疼痛及其合并症的循环基础。

慢性疼痛治疗效果不佳，并伴有许多发展为致残的合并症，如焦虑、抑郁和失眠。大量证据支持这样的观点，即疼痛和抗氧化抑郁症具有共同的神经生物学特征，并且可以相互强化，这具有重大的长期影响，因为合并症的发展会导致疼痛和情绪障碍的治疗效果较差。本文将回顾对慢性疼痛合并症的回路基础的理解的最新进展。