Adverse events are potentially associated with an IgG response after the BNT162b2 vaccination for severe acute respiratory syndrome coronavirus 2. In this study, we investigated the side effects of BNT162b2 vaccination using a health questionnaire and examined its relationship with IgG antibody titers. Serum samples were collected from participants 3 months after the second vaccination, just before the third vaccination, and 1 and 3 months after the third vaccination. A total of 505 participants who received three doses of vaccination were eligible for analysis. The results showed that post-vaccination body temperature correlated with anti-spike-receptor-binding domain (anti-S-RBD) antibody titers analyzed 3 months after the second (r = 0.30, p < 0.001) and third (r = 0.14, p < 0.001) vaccinations. Multivariate linear regression analysis revealed that age and severe swelling were negatively associated with log-transformed anti-S-RBD antibody levels, whereas sex (female), body temperature, and heat sensation were positively associated after the second vaccination. After the third vaccination, body temperature, and fatigue were positively associated with log-transformed anti-S-RBD antibody levels, and sex (female) was negatively associated. These results indicate that post-vaccination fever may be a marker of increased antibody titer.

不良事件可能与严重急性呼吸综合征冠状病毒 2 型 BNT162b2 疫苗接种后的 IgG 反应相关。在这项研究中，我们使用健康问卷调查了 BNT162b2 疫苗接种的副作用，并检查了其与 IgG 抗体滴度的关系。在第二次疫苗接种后 3 个月、第三次疫苗接种前以及第三次疫苗接种后 1 个月和 3 个月从参与者采集血清样本。共有 505 名接受三剂疫苗接种的参与者符合分析资格。结果显示，在第二次（r = 0.30，p < 0.001）和第三次（r = 0.14，r = 0.14，p < 0.001) 疫苗接种。多元线性回归分析显示，年龄和严重肿胀与对数转换的抗S-RBD抗体水平呈负相关，而性别（女性）、体温和热感在第二次疫苗接种后呈正相关。第三次疫苗接种后，体温和疲劳与对数转换的抗S-RBD抗体水平呈正相关，而性别（女性）呈负相关。这些结果表明，疫苗接种后发烧可能是抗体滴度增加的标志。