A screen-printed carbon electrode was used to develop a biosensor with an improved response and selectivity for detecting human epidermal growth factor receptor 2 (HER2). To investigate the performance of the biosensor, electrochemical characterizations such as impedance spectroscopy, differential pulse and cyclic voltammetry were used, in addition to Fourier transform infrared spectroscopy and atomic force microscopy. The biosensor responds in a quick manner, taking only 5 min to bind to the target protein. Furthermore, the results show that the nano-biosensor has a detection limit of 4.4 Pg/ml. The findings suggest that the biosensor can be used as a potential analytical tool for HER2 detection, particularly at low concentrations, which can be a tool used in the early detection of breast cancer.

丝网印刷碳电极用于开发具有改进的响应和选择性的生物传感器，用于检测人表皮生长因子受体 2 (HER2)。为了研究生物传感器的性能，除了傅里叶变换红外光谱和原子力显微镜外，还使用了阻抗谱、差分脉冲和循环伏安法等电化学表征。生物传感器反应迅速，仅需 5 分钟即可与目标蛋白结合。此外，结果表明纳米生物传感器的检测限为4.4 Pg/ml。研究结果表明，该生物传感器可用作 HER2 检测的潜在分析工具，尤其是在低浓度下，这可用作乳腺癌早期检测的工具。