Despite extensive coverage of a relationship between memory performance and executive function in the obsessive-compulsive disorder (OCD) literature, the relative contributions of specific aspects of executive control have remained elusive. We, therefore, extend our previous multilevel meta-analysis (Persson et al., 2021), where demand on executive function was the most significant determinant of memory deficits in OCD, and provide a finer-grained analysis of executive control via a segregation into top-down (attentional control, maintenance and updating, planning) and bottom-up (perceptual integration, perceptual salience) contributions. Our multilevel meta-analytic approach allowed us to accommodate the interdependency of 255 effect sizes from 131 studies, totaling 4,101 OCD patients. Results revealed that maintenance and updating (top-down) and perceptual integration (bottom-up) predicted memory performance generally, and specifically in those with clinical OCD. Exploratory analyses suggested that this effect may be somewhat different among subclinical OCD groups; however, these findings should be considered with conceptual and analytical caveats in mind. We explain these results via deficient sensory (perceptual integration) and working memory (maintenance and updating) gating mechanisms and propose a model to accommodate their expression in OC symptoms. In conclusion, our meta-analysis has expanded understanding of cognitive performance in OCD and identifies the possibility of untapped cognitive targets for intervention. (PsycInfo Database Record (c) 2023 APA, all rights reserved).

中文翻译：

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自上而下和自下而上对强迫症记忆性能的贡献：具有临床意义的多级荟萃分析。

尽管在强迫症 (OCD) 文献中广泛报道了记忆表现与执行功能之间的关系，但执行控制的特定方面的相对贡献仍然难以捉摸。因此，我们扩展了我们之前的多层次元分析（Persson 等人，2021），其中对执行功能的需求是强迫症记忆缺陷的最重要决定因素，并通过隔离对执行控制进行更细粒度的分析自上而下（注意力控制、维护和更新、规划）和自下而上（感知整合、感知显着性）的贡献。我们的多层次荟萃分析方法使我们能够容纳来自 131 项研究的 255 种效应大小的相互依赖性，共计 4,101 名强迫症患者。结果显示，维护和更新（自上而下）和知觉整合（自下而上）普遍预测记忆表现，特别是在那些患有临床强迫症的人中。探索性分析表明，这种影响在亚临床强迫症人群中可能有所不同；然而，在考虑这些调查结果时应牢记概念和分析上的注意事项。我们通过缺乏感觉（知觉整合）和工作记忆（维护和更新）门控机制来解释这些结果，并提出一个模型来适应它们在 OC 症状中的表达。总之，我们的荟萃分析扩大了对强迫症认知表现的理解，并确定了未开发的干预认知目标的可能性。（PsycInfo 数据库记录 (c) 2023 APA，保留所有权利）。