Plasmalogen is a major phospholipid of mammalian cell membranes. Recently it is becoming evident that the sn-1 vinyl-ether linkage in plasmalogen, contrasting to the ester linkage in the counterpart diacyl glycerophospholipid, yields differential molecular characteristics for these lipids especially related to hydrocarbon-chain order, so as to concertedly regulate biological membrane processes. A role played by NMR in gaining information in this respect, ranging from molecular to tissue levels, draws particular attention. We note here that a broad range of enzymes in de novo synthesis pathway of plasmalogen commonly constitute that of diacyl glycerophospholipid. This fact forms the basis for systematic crosstalk that not only controls a quantitative balance between these lipids, but also senses a defect causing loss of lipid in either pathway for compensation by increase of the counterpart lipid. However, this inherent counterbalancing mechanism paradoxically amplifies imbalance in differential effects of these lipids in a diseased state on membrane processes. While sharing of enzymes has been recognized, it is now possible to overview the crosstalk with growing information for specific enzymes involved. The overview provides a fundamental clue to consider cell and tissue type-dependent schemes in regulating membrane processes by plasmalogen and diacyl glycerophospholipid in health and disease.

缩醛磷脂是哺乳动物细胞膜的主要磷脂。最近，越来越明显的是，缩醛磷脂中的sn -1 乙烯基醚键与对应的二酰基甘油磷脂中的酯键不同，使这些脂质产生不同的分子特征，特别是与烃链顺序相关的分子特征，从而协同调节生物膜流程。核磁共振在获取这方面从分子到组织水平的信息方面所发挥的作用引起了特别关注。我们在此注意到，缩醛磷脂从头合成途径中的多种酶通常构成二酰基甘油磷脂的酶。这一事实构成了系统串扰的基础，系统串扰不仅控制这些脂质之间的定量平衡，而且还感知导致任一途径中脂质损失的缺陷，以通过增加对应脂质来补偿。然而，这种固有的平衡机制矛盾地放大了这些脂质在患病状态下对膜过程的不同影响的不平衡。虽然酶的共享已得到认可，但现在可以通过所涉及的特定酶的不断增长的信息来概述串扰。该概述为考虑在健康和疾病中通过缩醛磷脂和二酰基甘油磷脂调节膜过程的细胞和组织类型依赖性方案提供了基本线索。