Julia-Lythgoe olefination (or simply Julia olefination) is an olefination process between phenyl sulfones and aldehydes (or ketones) to give alkenes after alcohol functionalization and re-ductive elimination using sodium amalgam or SmI2. It is mainly used to synthesize E-alkenes and is a key step in numerous total syntheses of many natural products. This review exclusively deals with the Julia-Lythgoe olefination and concentrates mainly on the applications of this reaction in natural product synthesis covering literature up to 2021.

中文翻译：

---

Julia-lythgoe 烯化概述

Julia-Lythgoe 烯化（或简称 Julia 烯化）是苯砜和醛（或酮）之间的烯化过程，在醇官能化和使用钠汞齐或 SmI2 还原消除后得到烯烃。它主要用于合成E-烯烃，是许多天然产物全合成的关键步骤。本综述专门讨论 Julia-Lythgoe 烯化反应，主要关注该反应在天然产物合成中的应用，涵盖截至 2021 年的文献。