circular RNAs (circRNAs) have been considered novel biomarker candidates for human cancers, such as triple-negative breast cancer (TNBC). circ_0001006 was identified as a differentially expressed circRNA in metastatic breast cancer, but its significance and function in TNBC were unclear. The significance of circ_0001006 in TNBC was assessed and exploring its potential molecular mechanism to provide a therapeutic target for TNBC. circ_0001006 showed significant upregulation in TNBC and close association with patients’ histological grade, Ki67 level, and TNM stage. Upregulated circ_0001006 could predict a worse prognosis and high risk of TNBC patients. In TNBC cells, silencing circ_0001006 suppressed cell proliferation, migration, and invasion. In mechanism, circ_0001006 could negatively regulate miR-424-5p, which mediated the inhibition of cellular processes by circ_0001006 knockdown. Upregulated circ_0001006 in TNBC served as a poor prognosis predictor and tumor promoter via negatively regulating miR-424-5p.

中文翻译：

---

circRNA_0001006通过miR-424-5p预测预后并调控三阴性乳腺癌的细胞过程

环状 RNA (circRNA) 已被认为是人类癌症的新型生物标志物候选者，例如三阴性乳腺癌 (TNBC)。circ_0001006被鉴定为转移性乳腺癌中差异表达的circRNA，但其在TNBC中的意义和功能尚不清楚。评估circ_0001006在TNBC中的意义，探索其潜在的分子机制，为TNBC提供治疗靶点。circ_0001006 在 TNBC 中表现出显着上调，并且与患者的组织学分级、Ki67 水平和 TNM 分期密切相关。上调的 circ_0001006 可以预测 TNBC 患者的预后较差和高风险。在 TNBC 细胞中，沉默 circ_0001006 抑制了细胞增殖、迁移和侵袭。在机制上，circ_0001006可以负向调节miR-424-5p，它通过 circ_0001006 敲低介导了对细胞过程的抑制。TNBC 中上调的 circ_0001006 通过负调节 miR-424-5p 充当不良预后预测因子和肿瘤促进因子。