K homology-type splicing regulatory protein (KSRP) is emerging as a key player in cancer biology, and immunology. As a single-strand nucleic acid binding protein it functions in both transcriptional and post-transcriptional regulation, while facilitating multiple stages of RNA metabolism to affect proliferation and control cell fate. However, it must interact with other proteins to determine the fate of its bound substrate. Here we provide an minireview of this important regulatory protein and describe its complex subcellular functions to affect RNA metabolism, stability, miRNA biogenesis and maturation, stress granule function, metastasis, and inflammatory processes.

中文翻译：

---

K-同源型剪接调节蛋白：在癌症和免疫性疾病中的作用机制

K 同源型剪接调节蛋白 (KSRP) 正在成为癌症生物学和免疫学的关键参与者。作为一种单链核酸结合蛋白，它在转录和转录后调节中发挥作用，同时促进 RNA 代谢的多个阶段，从而影响增殖和控制细胞命运。然而，它必须与其他蛋白质相互作用才能决定其结合底物的命运。在这里，我们对这种重要的调节蛋白进行了简要回顾，并描述了其影响 RNA 代谢、稳定性、miRNA 生物发生和成熟、应激颗粒功能、转移和炎症过程的复杂亚细胞功能。