Mosquito-borne diseases present a significant threat to human health, with the possibility of outbreaks of new mosquito-borne diseases always looming. Unfortunately, current measures to combat these diseases such as vaccines and drugs are often either unavailable or ineffective. However, recent studies on microbiomes may reveal promising strategies to fight these diseases. In this review, we examine recent advances in our understanding of the effects of both the mosquito and vertebrate microbiomes on mosquito-borne diseases. We argue that the mosquito microbiome can have direct and indirect impacts on the transmission of these diseases, with mosquito symbiotic microorganisms, particularly Wolbachia bacteria, showing potential for controlling mosquito-borne diseases. Moreover, the skin microbiome of vertebrates plays a significant role in mosquito preferences, while the gut microbiome has an impact on the progression of mosquito-borne diseases in humans. As researchers continue to explore the role of microbiomes in mosquito-borne diseases, we highlight some promising future directions for this field. Ultimately, a better understanding of the interplay between mosquitoes, their hosts, pathogens, and the microbiomes of mosquitoes and hosts may hold the key to preventing and controlling mosquito-borne diseases.

中文翻译：

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微生物组对蚊媒疾病的影响。

蚊媒疾病对人类健康构成重大威胁，新的蚊媒疾病暴发的可能性总是迫在眉睫。不幸的是，目前对抗这些疾病的措施（例如疫苗和药物）往往要么不可用，要么无效。然而，最近对微生物组的研究可能揭示对抗这些疾病的有希望的策略。在这篇综述中，我们研究了我们对蚊子和脊椎动物微生物组对蚊媒疾病影响的理解的最新进展。我们认为，蚊子微生物组可以对这些疾病的传播产生直接和间接的影响，蚊子共生微生物，特别是沃尔巴克氏菌，显示出控制蚊媒疾病的潜力。此外，脊椎动物的皮肤微生物组在蚊子的偏好中起着重要作用，而肠道微生物组对人类蚊媒疾病的进展有影响。随着研究人员继续探索微生物组在蚊媒疾病中的作用，我们强调了该领域一些有前途的未来方向。最终，更好地了解蚊子、其宿主、病原体以及蚊子和宿主的微生物组之间的相互作用可能是预防和控制蚊媒疾病的关键。