It is critical to find efficient non-invasive prognostic factor for osteosarcoma. In this study, we demonstrated that serum protein of pro-surfactant protein B (pro-SFTPB) may be a potential diagnostic indicator in osteosarcoma. We found that serum pro-SFTPB was highly expressed in osteosarcoma patients and presented good diagnostic value to discern osteosarcoma patients from non-osteosarcoma control subjects. Serum pro-SFTPB was also significantly correlated with advanced clinical stage, distant metastasis, and shorter overall survival. In addition, serum pro-SFTPB was demonstrated to be an independent prognostic factor for osteosarcoma. Overall, our study demonstrated that serum pro-SFTPB may be a useful diagnostic factor for osteosarcoma.

中文翻译：

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血清前表面活性蛋白 B 与骨肉瘤患者的临床特征相关。

寻找有效的骨肉瘤非侵入性预后因素至关重要。在这项研究中，我们证明前表面活性剂蛋白 B (pro-SFTPB) 的血清蛋白可能是骨肉瘤的潜在诊断指标。我们发现血清pro-SFTPB在骨肉瘤患者中高表达，对于区分骨肉瘤患者和非骨肉瘤对照受试者具有良好的诊断价值。血清 pro-SFTPB 还与晚期临床分期、远处转移和较短的总生存期显着相关。此外，血清pro-SFTPB被证明是骨肉瘤的独立预后因素。总体而言，我们的研究表明血清 pro-SFTPB 可能是骨肉瘤的有用诊断因素。