Hypoxic pulmonary hypertension (HPH) is a life-threatening disease that occurs due to a lack of oxygen in the lungs, leading to an increase in pulmonary vascular resistance, right ventricular failure, and ultimately death. HPH is a multifactorial disorder that involves multiple molecular pathways, making it a challenge for clinicians to identify effective therapies. Pulmonary artery smooth muscle cells (PASMCs) play a crucial role in HPH pathogenesis by proliferating, resisting apoptosis, and promoting vascular remodelling. Curcumin, a natural polyphenolic compound, has shown potential as a therapeutic agent for HPH by reducing pulmonary vascular resistance, inhibiting vascular remodelling, and promoting apoptosis of PASMCs. Regulation of PASMCs could significantly inhibits HPH. However, curcumin has the disadvantages of poor solubility and low bioavailability, and its derivative WZ35 has better biosafety. Here, Cu-based metal organic frameworks (MOFCu ) was fabricated to encapsulate the curcumin analogue WZ35 (MOFCu @WZ35) for the inhibition of PASMCs proliferation. The authors found that the MOFCu @WZ35 could promote the death of PASMCs. Furthermore, the authors believed that this drug delivery system will effectively alleviate the HPH.

中文翻译：

---

通过铜基金属有机框架递送类姜黄素 WZ35 抑制肺动脉平滑肌细胞。

缺氧性肺动脉高压（HPH）是一种危及生命的疾病，由于肺部缺氧而发生，导致肺血管阻力增加、右心室衰竭，最终死亡。HPH 是一种多因素疾病，涉及多种分子途径，这给临床医生寻找有效的治疗方法带来了挑战。肺动脉平滑肌细胞（PASMC）通过增殖、抵抗细胞凋亡和促进血管重塑在 HPH 发病机制中发挥着至关重要的作用。姜黄素是一种天然多酚化合物，通过降低肺血管阻力、抑制血管重塑和促进 PASMC 凋亡，显示出作为 HPH 治疗剂的潜力。PASMCs 的调节可以显着抑制 HPH。但姜黄素存在溶解性差、生物利用度低的缺点，其衍生物WZ35具有更好的生物安全性。在这里，制备了铜基金属有机框架（MOFCu）来封装姜黄素类似物 WZ35（MOFCu @WZ35），以抑制 PASMC 增殖。作者发现 MOFCu @WZ35 可以促进 PASMC 死亡。此外，作者相信这种药物输送系统将有效缓解HPH。