Following the announcement of the pandemic of COVID-19 in December 2019, several studies focused on how to early predict the severity of the disease in symptomatic and asymptomatic patients. Many cytokines including interleukin-6, interleukin-8, and tumor necrotic factors have been concluded as strong indicators for COVID-19 infection. Additionally, miRNAs have been associated with dysregulation in the immune system. The aim of this study are the following: (1) to estimate the level of miRNA-16–2-3P, miRNA-618, IL-8, IL-1β as predictors for SARS-CoV-2 complications in PCR negative and positive patients; (2) to assess the biological role and effect of these miRNAs on SARS-CoV-2 pathogenicity. Our study showed that the level of IL-1β had been significantly associated with patient who need hospitalization, also the alteration of the level of miRNA-16–2-3P, miRNA-618 is positively correlated with the admission of these patients and influence the outcomes of SARS-cov-2 infection. Measurement of miRNA-16–2-3P, miRNA-618, IL-1β could be a good predictor of COVID-19 patient outcome. However the measurement of IL-8 levels during immune responses in the admitted and in ICU patients could have a prognostic value.

2019 年 12 月宣布 COVID-19 大流行后，多项研究重点关注如何早期预测有症状和无症状患者的疾病严重程度。许多细胞因子，包括白细胞介素 6、白细胞介素 8 和肿瘤坏死因子，已被认为是 COVID-19 感染的有力指标。此外，miRNA 与免疫系统失调有关。本研究的目的如下：(1) 估计 miRNA-16–2-3P、miRNA-618、IL-8、IL-1β 的水平作为 PCR 阴性和阳性中 SARS-CoV-2 并发症的预测因子患者; (2)评估这些miRNA对SARS-CoV-2致病性的生物学作用和影响。我们的研究表明IL-1β水平与患者是否需要住院显着相关，并且miRNA-16-2-3P、miRNA-618水平的变化与这些患者的入院呈正相关，并影响患者的住院治疗。 SARS-cov-2 感染的结果。miRNA-16–2-3P、miRNA-618、IL-1β 的测量可以很好地预测 COVID-19 患者的预后。然而，在入院患者和 ICU 患者免疫反应期间测量 IL-8 水平可能具有预后价值。