With the sustained prevalence and introduction of emerging drugs throughout the world there is a need for continued development and maintenance of platforms that enable rapid identification and characterization of unknown compounds. To complement existing efforts, a collaborative platform between the National Institute of Standards and Technology (NIST) and practicing forensic agencies is being deployed which enables laboratories to leverage techniques and expertise that may not exist at their facilities. Using this approach, unknown compounds are identified and characterized using a suite of analytical tools to obtain (1) a rapid preliminary identification followed by (2) a more complete characterization and confirmation of the preliminary identification. To demonstrate this platform, the characterization of three previously unreported analogs of phencyclidine (PCP) – POXP, PTHP, and P2AP – are described. A preliminary identification of the three substances was obtained using direct analysis in real time mass spectrometry (DART-MS) with confirmation by nuclear magnetic resonance (NMR) spectroscopy, gas chromatography mass spectrometry (GC–MS) and gas chromatography flame ionization detection (GC-FID).

随着新兴药物在世界范围内的持续流行和引入，需要继续开发和维护能够快速识别和表征未知化合物的平台。为了补充现有的努力，美国国家标准与技术研究院 (NIST) 与执业法医机构之间正在部署一个协作平台，使实验室能够利用其设施中可能不存在的技术和专业知识。使用这种方法，使用一套分析工具识别和表征未知化合物以获得 (1) 快速初步鉴定，然后 (2) 更完整的表征和初步鉴定的确认。为了展示这个平台，描述了三种以前未报道的苯环利定 (PCP) 类似物——POXP、PTHP 和 P2AP——的特性。通过实时质谱 (DART-MS) 直接分析，并通过核磁共振 (NMR) 光谱、气相色谱质谱 (GC–MS) 和气相色谱火焰离子化检测 (GC) 进行确认，初步鉴定了这三种物质-FID）。