Breast cancer is the major cancer that affects women all over the world. The awareness over past several decades has led to intensive screening and detection as well as successful treatments. Still, the breast cancer mortality is unacceptable and needs to be urgently addressed. Among many factors, inflammation has often been associated with tumorigenesis, including breast cancer. More than a third of all breast cancer deaths are marked by deregulated inflammation. The exact mechanisms are still not completely known but among the many putative factors, the epigenetic changes, particularly those mediated by non-coding RNAs are fascinating. microRNAs, long non-coding RNAs as well as circular RNAs seem to impact the inflammation in breast cancer which further highlights their important regulatory role in breast cancer pathogenesis. Understanding inflammation in breast cancer and its regulation by non-coding RNAs is the primary objective of this review article. We attempt to provide the most complete information on the topic in hopes of opening new areas of research and discoveries.

乳腺癌是影响全世界女性的主要癌症。过去几十年的认识导致了密集的筛查和检测以及成功的治疗。尽管如此，乳腺癌死亡率仍然令人无法接受，需要紧急解决。在许多因素中，炎症通常与肿瘤发生有关，包括乳腺癌。超过三分之一的乳腺癌死亡是以炎症失调为标志的。确切的机制尚不完全清楚，但在众多假定因素中，表观遗传变化，尤其是由非编码 RNA 介导的变化令人着迷。microRNA 、长链非编码RNA以及环状RNA似乎会影响乳腺癌的炎症，这进一步凸显了它们在乳腺癌发病机制中的重要调节作用。了解乳腺癌炎症及其非编码 RNA 的调节是这篇综述文章的主要目标。我们试图提供有关该主题的最完整的信息，以期开辟新的研究和发现领域。