Introduction: Increasing evidence suggests that microRNAs (miRNAs) and long noncoding RNAs (lncRNAs) have emerged as attractive targets in viral infections, including Human immunodeficiency virus (HIV). Objective: To deepen the understanding of the molecular mechanisms that lead to HIV and provide potential targets for the future development of molecular therapies for its treatment. Methods: Four miRNAs were selected as candidates based on a previous systematic review. A combination of bioinformatic analyses was performed to identify their target genes, lncRNAs and biological processes that regulate them. Results: In the constructed miRNA–mRNA network, 193 gene targets are identified. These miRNAs potentially control genes from several important processes, including signal transduction and cancer. LncRNA-XIST, lncRNA-NEAT1 and lncRNA-HCG18 interact with all four miRNAs. Conclusion: This preliminary result forms the basis for improving reliability in future studies to fully understand the role these molecules and their interactions play in HIV.

中文翻译：

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MIR-29A-3P、MIR-29C-3P、MIR-146B-5P 和 MIR-150-5P，它们在 HIV 感染中的靶基因和 Lncrnas：生物信息学研究

简介：越来越多的证据表明，microRNA (miRNA) 和长链非编码 RNA (lncRNA) 已成为病毒感染（包括人类免疫缺陷病毒 (HIV)）中有吸引力的靶标。目的：加深对导致艾滋病毒的分子机制的理解，并为未来开发治疗艾滋病毒的分子疗法提供潜在靶点。方法：根据之前的系统评价，选择四种 miRNA 作为候选者。结合生物信息学分析来识别它们的靶基因、lncRNA 和调节它们的生物过程。结果：在构建的 miRNA-mRNA 网络中，识别出 193 个基因靶标。这些 miRNA 可能控制多个重要过程的基因，包括信号转导和癌症。LncRNA-XIST、lncRNA-NEAT1 和 lncRNA-HCG18 与所有四种 miRNA 相互作用。结论：这一初步结果为提高未来研究的可靠性奠定了基础，以充分了解这些分子及其相互作用在 HIV 中的作用。