INTRODUCTION Myxoid soft tissue tumors represent a heterogenous group of neoplasms. The study presented our experience on cytopathology of myxoid soft tissue tumors on fine needle aspiration (FNA) and aimed to apply the recently proposed WHO system for reporting soft tissue cytopathology. MATERIAL AND METHODS We performed a 20-year retrospective search of our archives to identify all FNAs performed on myxoid soft tissue lesions. All cases were reviewed, and the WHO reporting system was applied. RESULTS 129 FNAs performed in 121 patients (62 males; 59 females) showed a prominent myxoid component, accounting for 2.4% of all soft tissue FNAs. The FNAs were performed on 111 (86.7%) primary tumors, 17 (13.2%) recurrent tumors, and one (0.8%) metastatic lesion. A spectrum of non-neoplastic and neoplastic lesions including both benign and malignant neoplasms was identified. Overall, the most common tumors identified were myxoid liposarcoma (27.1%), intramuscular myxoma (15.5%), and myxofibrosarcoma (13.1%). The sensitivity and specificity of FNA regarding the nature of the lesion (benign vs. malignant) were 98% and 100%, respectively. When the WHO reporting system was applied, the frequency of the categories was as follows: benign (7.8%), atypical (34.1%), soft tissue neoplasm of uncertain malignant potential (18.6%), suspicious for malignancy (3.1%), and malignant (36.4%). The risk of malignancy calculated in each category was as follows: benign (10%), atypical (31.8%), soft tissue neoplasm of uncertain malignant potential (50%), suspicious for malignancy (100%), and malignant (100%). CONCLUSION A diverse group of non-neoplastic and neoplastic lesions can show a prominent myxoid component on FNA. The WHO reporting system for soft tissue cytopathology is easily applicable and appears to correlate well with the malignant potential of myxoid tumors.

中文翻译：

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粘液样软组织肿瘤：细针抽吸和应用拟议的世界卫生组织软组织细胞病理学报告系统的 20 年经验。

简介 粘液样软组织肿瘤代表一组异质性肿瘤。该研究介绍了我们在细针抽吸 (FNA) 中对粘液样软组织肿瘤进行细胞病理学的经验，旨在应用最近提出的 WHO 系统来报告软组织细胞病理学。材料和方法 我们对我们的档案进行了 20 年的回顾性检索，以确定对粘液样软组织病变进行的所有 FNA。所有病例均经过审查，并采用世界卫生组织报告系统。结果 121 名患者（62 名男性；59 名女性）进行的 129 次 FNA 显示出明显的粘液样成分，占所有软组织 FNA 的 2.4%。对 111 个（86.7%）原发肿瘤、17 个（13.2%）复发肿瘤和 1 个（0.8%）转移病灶进行了 FNA。确定了一系列非肿瘤性和肿瘤性病变，包括良性和恶性肿瘤。总体而言，最常见的肿瘤是粘液样脂肪肉瘤（27.1%）、肌内粘液瘤（15.5%）和粘液纤维肉瘤（13.1%）。FNA 关于病变性质（良性与恶性）的敏感性和特异性分别为 98% 和 100%。应用WHO报告系统时，类别频率如下：良性（7.8%）、非典型（34.1%）、恶性潜能不确定的软组织肿瘤（18.6%）、可疑恶性肿瘤（3.1%）和恶性（36.4%）。各类别计算的恶性肿瘤风险如下：良性（10%）、非典型（31.8%）、恶性潜能不确定的软组织肿瘤（50%）、可疑恶性肿瘤（100%）和恶性（100%） 。结论 不同组的非肿瘤性和肿瘤性病变可在 FNA 上显示出显着的粘液样成分。世界卫生组织的软组织细胞病理学报告系统易于应用，并且似乎与粘液样肿瘤的恶性潜力密切相关。