INTRODUCTION Women with a current diagnosis or past history of Graves' disease (GD) are at risk of developing fetal thyrotoxicosis (FT) during pregnancy when they are inadequately treated, or because of placental passage of TSH receptor antibodies (TRAb). It is known that FT induced by high maternal thyroid hormone concentrations may result in infant (central) hypothyroidism. CASE PRESENTATION In a euthyroid woman with a history of GD treated with radioactive iodide (I131), persistently high levels of maternal TRAb resulted in recurrent FT during two separate pregnancies, followed by neonatal hyperthyroidism and infant central hypothyroidism. DISCUSSION This case demonstrates the novel insight that FT due to high fetal thyroid hormone concentrations stimulated by high maternal TRAb levels might also result in (central) hypothyroidism, requiring long-term evaluation of the hypothalamus-pituitary-thyroid axis in these children.

中文翻译：

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母体 TSH 受体刺激抗体引起的胎儿甲状腺毒症导致婴儿中枢性甲状腺功能减退症。

引言 当前诊断为 Graves 病 (GD) 或既往病史的女性在妊娠期间未得到充分治疗或由于 TSH 受体抗体 (TRAb) 的胎盘通过而有发生胎儿甲状腺毒症 (FT) 的风险。众所周知，由高母体甲状腺激素浓度引起的 FT 可能导致婴儿（中枢性）甲状腺功能减退症。案例介绍 在一名甲状腺功能正常的女性中，她有 GD 病史并接受了放射性碘 (I131) 治疗，母体 TRAb 水平持续升高导致两次妊娠期间 FT 复发，随后出现新生儿甲状腺功能亢进症和婴儿中枢性甲状腺功能减退症。讨